{"id":6938,"date":"2022-12-21T10:01:42","date_gmt":"2022-12-21T18:01:42","guid":{"rendered":"https:\/\/cms.helloklarity.com\/?p=6938"},"modified":"2024-02-14T10:14:51","modified_gmt":"2024-02-14T18:14:51","slug":"silenor-vs-tofranil","status":"publish","type":"post","link":"https:\/\/cms.helloklarity.com\/post\/silenor-vs-tofranil\/","title":{"rendered":"Silenor vs. Tofranil &#8211; What Is the Difference and Which One Should I Take?"},"content":{"rendered":"\n<p>Navigating depression can feel overwhelming, especially when first-line depression treatment hasn&#8217;t worked. Searching for effective antidepressant medicine takes some time, but&#8230;&nbsp;<\/p>\n\n\n\n<p><em>You\u2019re not alone, and you deserve to get the treatment you need when you need it! Not weeks later.&nbsp;<\/em><\/p>\n\n\n\n<p>In this article, we\u2019ll review Silenor and Tofranil, two antidepressant drugs that can be prescribed to treat major depressive disorder when first-line antidepressants like selective serotonin reuptake inhibitors (SSRIs) are not effective in reducing depression symptoms.<\/p>\n\n\n\n<p>We&#8217;ll discuss\u2014<\/p>\n\n\n\n<ul>\n<li>What class of antidepressants these two drugs belong to<\/li>\n\n\n\n<li>What symptoms each antidepressant is designed to treat<\/li>\n\n\n\n<li>Potential side effects of each antidepressant treatment<\/li>\n\n\n\n<li>Potential drug interactions for each antidepressant treatment<\/li>\n\n\n\n<li>The costs, doses, and formulations for each antidepressant<\/li>\n\n\n\n<li>Drug warnings for each antidepressant<\/li>\n\n\n\n<li>Plus, some frequently asked questions our mental health providers often receive!<\/li>\n<\/ul>\n\n\n\n<p>Klarity connects people with board-certified mental health providers who can diagnose and prescribe treatment for a variety of mental health issues, including<a href=\"https:\/\/www.klarityadhd.com\/depression\/\" target=\"_blank\" rel=\"noopener\"> depression<\/a>.<\/p>\n\n\n\n<p>If you want to talk to a medical provider about your treatment-resistant depression and are exploring different antidepressants, then <a href=\"https:\/\/care.klarityadhd.com\/assessment\/get-started\" target=\"_blank\" rel=\"noopener\">schedule an appointment<\/a>, and we\u2019ll match you with a licensed provider in your state <strong>within 48 hours<\/strong>.&nbsp;<\/p>\n\n\n\n<p><em>This article discusses suicide, suicidal ideation, and self-harm. If you or someone you know is experiencing suicidal thoughts or is in crisis, contact the Suicide Prevention Lifeline immediately at 800-273-8255.<\/em><\/p>\n\n\n\n<table id=\"tablepress-85\" class=\"tablepress tablepress-id-85 tablepress-responsive\">\n<thead>\n<tr class=\"row-1 odd\">\n\t<th class=\"column-1\"><\/th><th class=\"column-2\">Tofranil<\/th><th class=\"column-3\">Silenor<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-hover\">\n<tr class=\"row-2 even\">\n\t<td class=\"column-1\"><strong>Drug Class<\/strong><\/td><td class=\"column-2\">Tricyclic antidepressant<\/td><td class=\"column-3\">Tricyclic antidepressant<\/td>\n<\/tr>\n<tr class=\"row-3 odd\">\n\t<td class=\"column-1\"><strong>Brand \/ Generic Status<\/strong><\/td><td class=\"column-2\">Generic (Brand name: Silenor)<br \/>\n<br \/>\n<\/td><td class=\"column-3\">Brand name for Silenor<\/td>\n<\/tr>\n<tr class=\"row-4 even\">\n\t<td class=\"column-1\"><strong>Form(s) of the Drug<\/strong><\/td><td class=\"column-2\">Immediate-release tablets <br \/>\n\u2022 Shapes indicate dosage<br \/>\n<\/td><td class=\"column-3\">\u2022 Immediate-release capsules<br \/>\n\u2022 Immediate-release tablets<br \/>\n\u2022 Clear, blueberry-mint flavored liquid suspension<br \/>\n\u2022 Topical cream (for itching)<\/td>\n<\/tr>\n<tr class=\"row-5 odd\">\n\t<td class=\"column-1\"><strong>Standard Dosage<\/strong><\/td><td class=\"column-2\">Immediate-release tablets: <br \/>\n\u2022 10mg triangular tablet<br \/>\n\u2022 25mg small round tablet<br \/>\n\u2022 50mg large round tablet<br \/>\n<\/td><td class=\"column-3\">Immediate-release capsule:<br \/>\n\u2022 10mg<br \/>\n\u2022 25mg<br \/>\n\u2022 50mg<br \/>\n\u2022 75mg<br \/>\n\u2022 100mg<br \/>\n\u2022 150mg<br \/>\n<br \/>\nImmediate-release tablets:<br \/>\n\u2022 3mg<br \/>\n\u2022 6mg<br \/>\n<br \/>\nLiquid suspension: <br \/>\n\u2022 10mg per dose<br \/>\n<br \/>\nTopical cream:<br \/>\n\u2022 5% formula<\/td>\n<\/tr>\n<tr class=\"row-6 even\">\n\t<td class=\"column-1\"><strong>Conditions Treated<\/strong><\/td><td class=\"column-2\">FDA-approved uses:<br \/>\n\u2022 Major depressive disorder <br \/>\n<br \/>\nOff-label uses: <br \/>\n\u2022 Bulimia<br \/>\n\u2022 Nerve Pain<br \/>\n\u2022 Panic Disorder<br \/>\n\u2022 Irritable bowel syndrome (IBS)<br \/>\n\u2022 ADHD<br \/>\n\u2022 Enuresis in children<br \/>\n<br \/>\n<\/td><td class=\"column-3\">FDA-approved uses:<br \/>\n\u2022 Major depressive disorder<br \/>\n\u2022 Anxiety disorder<br \/>\n\u2022 OCD<br \/>\n<br \/>\nOff-label uses: <br \/>\n\u2022 Itchiness due to atopic dermatitis, pruritus, or lichen simplex chronicus<br \/>\n\u2022 Topical neuropathic pain<\/td>\n<\/tr>\n<tr class=\"row-7 odd\">\n\t<td class=\"column-1\"><strong>Cost<\/strong><\/td><td class=\"column-2\">Generic form (imipramine): <br \/>\n\u2022 $10 for a 30-day supply<br \/>\n<br \/>\nBrand name: <br \/>\n\u2022 $430 for a 30-day supply<br \/>\n<\/td><td class=\"column-3\">Generic form (doxepin)<br \/>\n\u2022 $36 to $90 for a 30-day supply<br \/>\n\u2022 $8 for a 30-day supply (with coupons or discounts) <br \/>\n<br \/>\nBrand name: <br \/>\n\u2022 $93 to $240 for a 30-day supply<\/td>\n<\/tr>\n<tr class=\"row-8 even\">\n\t<td class=\"column-1\"><strong>Side-Effects<\/strong><\/td><td class=\"column-2\">Common side effects: <br \/>\n\u2022 Mood\/behavior changes<br \/>\n\u2022 Anxiety<br \/>\n\u2022 Difficulty sleeping<br \/>\n\u2022 Agitation, hostility, and aggression<br \/>\n\u2022 Increased depression and suicidal thoughts<br \/>\n\u2022 Blurred vision<br \/>\n\u2022 Lightheadedness<br \/>\n\u2022 Fever<br \/>\n\u2022 Hallucinations<br \/>\n\u2022 Confusion<br \/>\n\u2022 Pain or difficulty urinating<br \/>\n\u2022 Seizures<br \/>\n\u2022 Difficulties with sex<br \/>\n\u2022 Constipation<br \/>\n\u2022 Nausea and vomiting<br \/>\n\u2022 Diarrhea<br \/>\n<\/td><td class=\"column-3\">Common side effects:<br \/>\n\u2022 Agitation, confusion <br \/>\n\u2022 Black, tarry stools, bleeding gums, blood in urine or stool<br \/>\n\u2022 Blurred vision <br \/>\n\u2022 A sensation of burning, itching, or \u201cpins and needles\u201d on the skin<br \/>\n\u2022 Chest pain or tightness, fast or irregular heartbeat<br \/>\n\u2022 Chills, cold sweats <br \/>\n\u2022 Urinary retention <br \/>\n\u2022 Dizziness upon standing, loss of consciousness <br \/>\n\u2022 Headache <br \/>\n\u2022 Hearing loss<br \/>\n\u2022 Muscle spasms, stiffness, twitching <br \/>\n\u2022 Seizures <br \/>\n<br \/>\nSerious side effects: <br \/>\n\u2022 Unusual thoughts or behavior<br \/>\n\u2022 Hallucinations<br \/>\n\u2022 Depression <br \/>\n\u2022 Suicidal ideation<br \/>\n\u2022 Seizures<br \/>\n\u2022 Lightheadedness<br \/>\n\u2022 Eye or chest pain<\/td>\n<\/tr>\n<tr class=\"row-9 odd\">\n\t<td class=\"column-1\"><strong>Warnings For Use<\/strong><\/td><td class=\"column-2\">Drug interactions: <br \/>\n\u2022 MAOIs<br \/>\n\u2022 SSRIs<br \/>\n\u2022 SNRIs<br \/>\n\u2022 Blood pressure medication<br \/>\n\u2022 Anticholinergics<br \/>\n\u2022 Digoxin<br \/>\n\u2022 Disopyramide<br \/>\n\u2022 Valproic acid<br \/>\n\u2022 Thyroid supplements <br \/>\n<br \/>\n<\/td><td class=\"column-3\">Drug interactions:<br \/>\n\u2022 Thyroid supplements <br \/>\n\u2022 Anticholinergic drugs <br \/>\n\u2022 Some blood pressure medications<br \/>\n\u2022 MAOIs <br \/>\n\u2022 SSRIs <br \/>\n\u2022 St. John's Wort<br \/>\n\u2022 Cimetidine<br \/>\n\u2022 Terbinafine<br \/>\n\u2022 Drugs to treat irregular heart rate<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-85 from cache -->\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Tofranil and Silenor Are the Same Class of Drugs (Tricyclics)<\/strong><\/h2>\n\n\n\n<p>Tofranil (Imipramine) and Silenor (Doxepin) are tricyclics, a class of antidepressants developed in the 1950s. These medications are primarily prescribed to treat major depressive disorder (MDD) but also have other off-label uses, such as treating anxiety disorders or managing chronic pain.<\/p>\n\n\n\n<p>Tricyclics are <em>nonselective<\/em> antidepressants meaning they affect much more serotonin receptors than other antidepressants like SSRIs or SNRIs, which are newer antidepressants that are <em>selective.<\/em><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>What Are Tricyclics?<\/strong><\/h3>\n\n\n\n<p>Tricyclics work by blocking the reuptake of certain neurotransmitters in the brain, which can help improve mood and reduce symptoms of depression. Tricyclics don\u2019t work for everyone, but they can be an effective means of treatment for some people based on their health history and current diagnosis, such as treatment-resistant depression.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Tofranil and Silenor Are Both Used To Treat Major Depressive Disorder<\/strong><\/h2>\n\n\n\n<p>Tofranil and Silenor are prescription medications used to treat major depressive disorder. Each drug has its own forms, doses, and side effects, and you should always consult your mental health provider before taking a new medication.&nbsp;&nbsp;<\/p>\n\n\n\n<p>Though Tofranil and Doxepin are in the same class of medication, it&#8217;s important to understand that they are different antidepressants and each will affect your mind and body differently.<\/p>\n\n\n\n<p>Let&#8217;s compare these two antidepressant medications\u2014<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>What Else Does Tofranil Treat?<\/strong><\/h3>\n\n\n\n<p>Tofranil is primarily used to treat symptoms of MDD, but it may also be used off-label to treat other conditions. The FDA has an approval system where a series of tests determines whether or not a medication will be an effective treatment for a particular issue. Off-label use is when a medication isn\u2019t approved for a certain issue, but it\u2019s proven to be an effective treatment.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Off-label Uses for Tofranil<\/strong><\/h4>\n\n\n\n<p>Tofranil is FDA-approved to treat major depressive disorder. Off-label uses may include:<\/p>\n\n\n\n<ol>\n<li><strong>Anxiety disorders<\/strong>: Some healthcare providers might prescribe Tofranil for generalized anxiety disorder, panic disorder, or social anxiety disorder.<\/li>\n\n\n\n<li><strong>Neuropathic pain<\/strong>: Tofranil has been used to manage chronic neuropathic pain, such as diabetic neuropathy or post-herpetic neuralgia.<\/li>\n\n\n\n<li><strong>Fibromyalgia<\/strong>: Tofranil may help manage pain and improve sleep in fibromyalgia patients.<\/li>\n\n\n\n<li><strong>Migraine prophylaxis<\/strong>: Tofranil has been used as a preventive treatment for migraine headaches.<\/li>\n\n\n\n<li><strong>Irritable bowel syndrome (IBS)<\/strong>: Tricyclic antidepressants like Tofranil may help manage abdominal pain and other IBS symptoms.<\/li>\n\n\n\n<li><strong>Chronic fatigue syndrome<\/strong>: Some healthcare providers might prescribe Tofranil to help alleviate symptoms of chronic fatigue syndrome.<\/li>\n\n\n\n<li><strong>Insomnia<\/strong>: Tofranil may be prescribed at low doses for patients who struggle with sleep.<\/li>\n<\/ol>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>What Else Does Silenor Treat?<\/strong><\/h3>\n\n\n\n<p>Silenor is also primarily prescribed to treat MDD and anxiety. Since it increases the levels of certain chemicals in the brain responsible for regulating mood, it\u2019s also used off-label to treat other conditions.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Off-label Uses for Silenor<\/strong><\/h4>\n\n\n\n<p>Off-label uses for Silenor may include:<\/p>\n\n\n\n<ol>\n<li><strong>Chronic urticaria<\/strong>: Silenor has antihistamine properties, so it has been used to treat chronic urticaria (hives) in some cases.<\/li>\n\n\n\n<li><strong>Neuropathic pain<\/strong>: Like other tricyclic antidepressants, Silenor may be prescribed for the management of neuropathic pain, such as diabetic neuropathy or post-herpetic neuralgia.<\/li>\n\n\n\n<li><strong>Migraine prophylaxis<\/strong>: Like Tofranil, Silenor has been used as a preventive treatment for migraine headaches.<\/li>\n\n\n\n<li><strong>Fibromyalgia<\/strong>: Some evidence suggests that Silenor may help manage pain and improve sleep for people with fibromyalgia.<\/li>\n\n\n\n<li><strong>Irritable bowel syndrome (IBS)<\/strong>: Tricyclic antidepressants like Silenor can help manage IBS symptoms.<\/li>\n\n\n\n<li><strong>Pruritus<\/strong>: Silenor\u2019s antihistamine properties may also make it useful for treating pruritus (itching) related to various skin conditions.<\/li>\n\n\n\n<li><strong>Chronic pain<\/strong>: Silenor may be prescribed for managing chronic pain conditions, such as chronic low back pain or chronic tension-type headaches.<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Doses, Dosage Form, and Side Effects of Silenor<\/strong><\/h2>\n\n\n\n<p>Silenor comes in different doses and forms that contribute to the overall cost of the medication. Depending on your recommended dose, you may experience common side effects, and it\u2019s important to know how your body might respond. Additionally, silenor interacts with several drugs, so you should tell your care provider about any other medications you take.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Common Silenor Doses and Forms<\/strong><\/h3>\n\n\n\n<p>Silenor is available in oral capsule, oral solution, and topical form. The recommended starting dose for adults is 75 mg daily, divided into three smaller doses and taken at bedtime. Your dose may increase gradually, up to a maximum of 300 mg per day.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Common Silenor Side Effects<\/strong><\/h3>\n\n\n\n<p>Silenor can cause several common side effects. These side effects are usually mild and may disappear as your body adjusts to the medication.<\/p>\n\n\n\n<p>Common Silenor side effects include:<\/p>\n\n\n\n<ul>\n<li>Drowsiness<\/li>\n\n\n\n<li>Dizziness<\/li>\n\n\n\n<li>Dry mouth<\/li>\n\n\n\n<li>Blurred vision<\/li>\n\n\n\n<li>Constipation<\/li>\n\n\n\n<li>Difficulty urinating<\/li>\n\n\n\n<li>Nausea and vomiting<\/li>\n\n\n\n<li>Stomach pain<\/li>\n\n\n\n<li>Weight gain<\/li>\n\n\n\n<li>Changes in taste<\/li>\n<\/ul>\n\n\n\n<p>However, if these side effects persist or if you experience any severe side effects, such as worsening depression, suicidal ideation, difficulty breathing, or swelling of the face, lips, tongue, or throat, you should contact your care provider right away.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Common Silenor Drug Interactions<\/strong><\/h3>\n\n\n\n<p>Silenor can interact with other medications and substances, such as alcohol and certain herbal supplements. There are also 661 drugs that Silenor interacts with, including 134 major interactions, 502 moderate interactions, and 25 minor interactions.&nbsp;<\/p>\n\n\n\n<p>Of the most frequently checked medications, Silenor has major interactions with Cymbalta, Flexeril, Lexapro, Topamax, and Zoloft.&nbsp;<\/p>\n\n\n\n<p>Moderate interactions include:<\/p>\n\n\n\n<ul>\n<li>Abilify<\/li>\n\n\n\n<li>Adderall<\/li>\n\n\n\n<li>Ambien<\/li>\n\n\n\n<li>Benadryl<\/li>\n\n\n\n<li>Klonopin<\/li>\n\n\n\n<li>Lamictal<\/li>\n\n\n\n<li>Lyrica<\/li>\n\n\n\n<li>Norco<\/li>\n\n\n\n<li>Seroquel<\/li>\n\n\n\n<li>Synthroid<\/li>\n\n\n\n<li>Xanax<\/li>\n\n\n\n<li>Zyrtec<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>How Much Does Silenor Cost?<\/strong><\/h3>\n\n\n\n<p>The cost of Silenor depends on the pharmacy you use, your recommended dose, and if you have insurance. You can expect to pay anywhere from $4.26 to $42.15 monthly for 30 capsules of 75 mg. Talk to your provider about using the generic form Silenor to save money.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Doses, Dosage Form, and Side Effects of Tofranil<\/strong><\/h2>\n\n\n\n<p>Like Silenor, Tofranil also comes in several doses and forms and has its own set of side effects. It also interacts with a series of other medications, so you must tell your care provider about any other medicines you\u2019re taking.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Common Tofranil Doses and Forms<\/strong><\/h3>\n\n\n\n<p>There are several doses and forms of Tofranil available, including tablets, capsules, and a liquid form. Common doses are between 10 and 200 mg daily, with the typical dose starting at 75 mg. Your care provider will determine the right dose based on your symptoms and other factors, like your health history.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Common Tofranil Side Effects<\/strong><\/h3>\n\n\n\n<p>Tofranil can cause some side effects. You must contact your mental health provider if these side effects persist or become severe.<\/p>\n\n\n\n<p>Common side effects include:<\/p>\n\n\n\n<ul>\n<li>Weight gain or loss<\/li>\n\n\n\n<li>Dry mouth<\/li>\n\n\n\n<li>Vision issues<\/li>\n\n\n\n<li>Headache<\/li>\n\n\n\n<li>Drowsiness<\/li>\n\n\n\n<li>Constipation<\/li>\n\n\n\n<li>Nausea and vomiting<\/li>\n\n\n\n<li>Loss of appetite<\/li>\n\n\n\n<li>Diarrhea<\/li>\n\n\n\n<li>Stomach cramps<\/li>\n\n\n\n<li>Tingly feeling<\/li>\n\n\n\n<li>Weakness<\/li>\n\n\n\n<li>Lack of coordination<\/li>\n\n\n\n<li>Ringing in your ears<\/li>\n\n\n\n<li>Breast swelling<\/li>\n\n\n\n<li>Decreased sex drive<\/li>\n\n\n\n<li>Impotence<\/li>\n\n\n\n<li>Difficulty orgasming<\/li>\n<\/ul>\n\n\n\n<p>If you experience any of the following serious side effects, contact your healthcare provider immediately.<\/p>\n\n\n\n<ul>\n<li>Easy bruising or bleeding<\/li>\n\n\n\n<li>Fever<\/li>\n\n\n\n<li>Sore throat<\/li>\n\n\n\n<li>Dark urine<\/li>\n\n\n\n<li>Yellowing eyes or skin<\/li>\n\n\n\n<li>New or worsening chest pain<\/li>\n\n\n\n<li>Irregular heartbeat<\/li>\n\n\n\n<li>Sudden numbness<\/li>\n\n\n\n<li>Purple or red spots under the skin<\/li>\n\n\n\n<li>Confusion<\/li>\n\n\n\n<li>New or worsening depression<\/li>\n\n\n\n<li>Suicidal ideation<\/li>\n\n\n\n<li>Seizures<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Common Tofranil Drug Interactions<\/strong><\/h3>\n\n\n\n<p>Tofranil interacts with 690 drugs, with 134 major interactions, 529 moderate interactions, and 27 minor interactions. Major interactions occur with&nbsp;<\/p>\n\n\n\n<ul>\n<li>Cymbalta<\/li>\n\n\n\n<li>Celexa<\/li>\n\n\n\n<li>Lexapro<\/li>\n\n\n\n<li>Paxil<\/li>\n\n\n\n<li>Prozac<\/li>\n\n\n\n<li>Trazodone<\/li>\n\n\n\n<li>Zoloft<\/li>\n<\/ul>\n\n\n\n<p>Moderate interactions include:<\/p>\n\n\n\n<ul>\n<li>Adderall<\/li>\n\n\n\n<li>Ambien<\/li>\n\n\n\n<li>Ativan<\/li>\n\n\n\n<li>Elavil<\/li>\n\n\n\n<li>Gabapentin<\/li>\n\n\n\n<li>Klonopin<\/li>\n\n\n\n<li>Lamictal<\/li>\n\n\n\n<li>Levothyroxine&nbsp;<\/li>\n\n\n\n<li>Lisinopril<\/li>\n\n\n\n<li>Seroquel<\/li>\n\n\n\n<li>Synthroid<\/li>\n\n\n\n<li>Xanax<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>How Much Does Tofranil Cost?<\/strong><\/h3>\n\n\n\n<p>The cost of Tofranil varies depending on your dose, pharmacy, and insurance coverage. The price ranges from $12.22 to $53.60 for 90 tablets at 25 mg. You should also consider asking about Imipramine, the generic form of Tofranil, as it\u2019s often less expensive.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Other Tricyclic Side Effects<\/strong><\/h2>\n\n\n\n<p>While they can be effective for many people, tricyclic antidepressants can have other potentially harmful side effects. These adverse effects could include serotonin syndrome, pregnancy and breastfeeding complications.An increased risk of bleeding could also occur due to taking blood thinner medication like Warfarin<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>What is Serotonin Syndrome?<\/strong><\/h3>\n\n\n\n<p>One potential side effect of tricyclic antidepressants is serotonin syndrome, which occurs when there\u2019s too much serotonin in the body. Symptoms of serotonin syndrome include agitation, hallucinations, and rapid heartbeat. If you experience these symptoms, contact your care provider immediately.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Pregnancy and Breastfeeding on Tricyclics<\/strong><\/h3>\n\n\n\n<p>Another potential concern with tricyclic antidepressants is using them during pregnancy and breastfeeding. Taking tricyclics while pregnant can lead to preterm birth, respiratory distress, neonatal convulsions, or low birth weight. It\u2019s important to talk to your healthcare provider about the potential risks and benefits of taking a tricyclic antidepressant during pregnancy.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Increased Bleeding Risk With Tricyclics<\/strong><\/h3>\n\n\n\n<p>Tricyclic antidepressants can also increase the risk of bleeding if you\u2019re taking a blood thinner like Warfarin. If you are taking a tricyclic antidepressant and planning surgery or dental work, let your care provider know beforehand. You may need to stop taking the medication for a period of time before and after the procedure.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Black Box Warning With Antidepressants<\/strong><\/h3>\n\n\n\n<p>The Food and Drug Administration (FDA) requires a black box warning on all antidepressants, including tricyclic antidepressants. This warning states that antidepressants may increase the risk of suicidal thoughts and behaviors in children, teenagers, and young adults. Monitor any changes in mood or behavior while taking a tricyclic antidepressant.<\/p>\n\n\n\t\t<div data-elementor-type=\"page\" data-elementor-id=\"15401\" class=\"elementor elementor-15401\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c521b1f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c521b1f\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1e5f769\" data-id=\"1e5f769\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-8537e6b elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8537e6b\" data-element_type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-f020c0d\" data-id=\"f020c0d\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2478e2a elementor-widget__width-auto elementor-widget elementor-widget-heading\" data-id=\"2478e2a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.19.0 - 07-02-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-large\">Licensed providers on Klarity provide personalized treatment. \nFind a provider that matches your needs and preferences.<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-87df69e elementor-widget elementor-widget-spacer\" data-id=\"87df69e\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.19.0 - 07-02-2024 *\/\n.elementor-column .elementor-spacer-inner{height:var(--spacer-size)}.e-con{--container-widget-width:100%}.e-con-inner>.elementor-widget-spacer,.e-con>.elementor-widget-spacer{width:var(--container-widget-width,var(--spacer-size));--align-self:var(--container-widget-align-self,initial);--flex-shrink:0}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container,.e-con>.elementor-widget-spacer>.elementor-widget-container{height:100%;width:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer{height:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner{height:var(--container-widget-height,var(--spacer-size))}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty,.e-con>.elementor-widget-spacer.elementor-widget-empty{position:relative;min-height:22px;min-width:22px}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon,.e-con>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon{position:absolute;top:0;bottom:0;left:0;right:0;margin:auto;padding:0;width:22px;height:22px}<\/style>\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-76f1234 elementor-widget-tablet__width-inherit elementor-tablet-align-center elementor-align-center elementor-widget__width-auto elementor-widget elementor-widget-button\" data-id=\"76f1234\" data-element_type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_on&quot;:[&quot;mobile&quot;],&quot;sticky_offset_mobile&quot;:0,&quot;sticky_effects_offset_mobile&quot;:0,&quot;sticky_offset&quot;:0,&quot;sticky_effects_offset&quot;:0}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/care.helloklarity.com\/assessment\/get-started?utm_source=blog&#038;utm_medium=cta&#038;utm_campaign=blue\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Find a provider<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Silenor and Tofranil Frequently Asked Questions<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>What is Silenor?<\/strong><\/h3>\n\n\n\n<p>Silenor is a tricyclic antidepressant prescription medication commonly used to treat symptoms of depression and anxiety.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>What is Tofranil?<\/strong><\/h3>\n\n\n\n<p>Tofranil is another tricyclic antidepressant medication that treats symptoms of depression.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Are Silenor and Tofranil the same class of drug?<\/strong><\/h3>\n\n\n\n<p>Yes, Silenor and Tofranil are tricyclic antidepressants, meaning they belong to the same class of drugs. While they are within the same drug class, they have their own unique side effects and warnings, and you should consult with a licensed professional before taking either one.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>What\u2019s better for anxiety? Silenor or Tofranil?<\/strong><\/h3>\n\n\n\n<p>Silenor is FDA-approved to treat anxiety, while Tofranil is not. Tofranil is used to treat some panic disorders in an off-label capacity, but that\u2019s not its primary intended use. The right medication depends on your current symptoms and your care provider\u2019s recommendations.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>What\u2019s better for depression? Silenor or Tofranil?<\/strong><\/h3>\n\n\n\n<p>Both Silenor and Tofranil are tricyclic antidepressant medications commonly used to treat MDD. Tofranil is a first-choice medication when it comes to treating symptoms of depression, while Silenor is a second-choice medication due to its many side effects. Your mental health provider will recommend the best option for you.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Can I drive on antidepressants like Silenor or Tofranil?<\/strong><\/h3>\n\n\n\n<p>It is generally safe to drive while taking Silenor or Tofranil as long as you do not experience any side effects that could impair your ability to operate a vehicle. Before getting behind the wheel, you should wait until you\u2019ve taken a few doses to understand how your body responds.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Can I drink alcohol on Silenor or Tofranil?<\/strong><\/h3>\n\n\n\n<p>You should not drink alcohol while taking Silenor or Tofranil. Alcohol can interact with these medications, increasing the risk of adverse side effects and worsening symptoms of depression and anxiety. If you do choose to drink while taking Silenor or Tofranil, only do so in moderation and talk to your healthcare provider about any potential risks.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Does it matter what time of day I take Silenor or Tofranil?<\/strong><\/h3>\n\n\n\n<p>It is generally recommended that you take Silenor or Tofranil at the same time each day to help maintain a consistent level of the medication in your body. Both drugs can make you tired, so it\u2019s best to take them before bed.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Klarity Can Help You Access Depression Treatment Online<\/strong><\/h2>\n\n\n\n<p>If you have treatment-resistant depression and are looking to try new antidepressants like Silenor and Tofranil, Klarity can help. We make accessing online depression treatment easy!<\/p>\n\n\n\n<p><a href=\"https:\/\/care.klarityadhd.com\/assessment\/get-started\" target=\"_blank\" rel=\"noopener\">Get started with online depression treatment<\/a> in as little as <strong>48 hours<\/strong> when you book an appointment on Klarity.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-layout-1 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>Sources:<\/p>\n\n\n\n<p>Mayo Clinic Staff. \u201c\u200b\u200b<a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/depression\/in-depth\/antidepressants\/art-20046983\" target=\"_blank\" rel=\"noopener\">Tricyclic antidepressants and tetracyclic antidepressants<\/a>\u201d <em>Mayo Clinic<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/depression\/in-depth\/antidepressants\/art-20046983\" target=\"_blank\" rel=\"noopener\">https:\/\/www.mayoclinic.org\/diseases-conditions\/depression\/in-depth\/antidepressants\/art-20046983<\/a><\/p>\n\n\n\n<p>\u201cDoxepin Side Effects\u201d <em>Drugs.com<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/www.drugs.com\/sfx\/doxepin-side-effects.html\" target=\"_blank\" rel=\"noopener\">https:\/\/www.drugs.com\/sfx\/doxepin-side-effects.html<\/a><\/p>\n\n\n\n<p>Femi Aremu. \u201cDoxepin, Oral Capsule\u201d <em>Healthline<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/www.healthline.com\/health\/drugs\/doxepin-oral-capsule#side-effects\" target=\"_blank\" rel=\"noopener\">https:\/\/www.healthline.com\/health\/drugs\/doxepin-oral-capsule#side-effects<\/a><\/p>\n\n\n\n<p>\u201cDoxepin Interactions\u201d <em>Drugs.com<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/www.drugs.com\/drug-interactions\/doxepin.html\" target=\"_blank\" rel=\"noopener\">https:\/\/www.drugs.com\/drug-interactions\/doxepin.html<\/a><\/p>\n\n\n\n<p>\u201cDoxepin\u201d <em>GoodRx<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/www.goodrx.com\/doxepin\" target=\"_blank\" rel=\"noopener\">https:\/\/www.goodrx.com\/doxepin<\/a><\/p>\n\n\n\n<p>John P. Cunha. \u201cSide Effects Center\u201d <em>RxList<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/www.rxlist.com\/tofranil-side-effects-drug-center.htm\" target=\"_blank\" rel=\"noopener\">https:\/\/www.rxlist.com\/tofranil-side-effects-drug-center.htm<\/a><\/p>\n\n\n\n<p>\u201cTofranil Interactions\u201d <em>Drugs.com<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/www.drugs.com\/drug-interactions\/imipramine,tofranil.html\" target=\"_blank\" rel=\"noopener\">https:\/\/www.drugs.com\/drug-interactions\/imipramine,tofranil.html<\/a><\/p>\n\n\n\n<p>\u201cTofranil\u201d <em>RxList<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/www.rxlist.com\/tofranil-drug.htm\" target=\"_blank\" rel=\"noopener\">https:\/\/www.rxlist.com\/tofranil-drug.htm<\/a><\/p>\n\n\n\n<p>IBM Micromedex. \u201cImipramine (Oral Route)\u201d <em>Mayo Clinic<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/imipramine-oral-route\/proper-use\/drg-20072148\" target=\"_blank\" rel=\"noopener\">https:\/\/www.mayoclinic.org\/drugs-supplements\/imipramine-oral-route\/proper-use\/drg-20072148<\/a><\/p>\n\n\n\n<p>\u201cGeneric Tofranil\u201d <em>GoodRx<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/www.goodrx.com\/tofranil?form=tablet&amp;dosage=25mg&amp;quantity=90&amp;label_override=imipramine-hydrochloride\" target=\"_blank\" rel=\"noopener\">https:\/\/www.goodrx.com\/tofranil?form=tablet&amp;dosage=25mg&amp;quantity=90&amp;label_override=imipramine-hydrochloride<\/a><\/p>\n\n\n\n<p>\u201cSerotonin Syndrome\u201d <em>Mayo Clinic<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/serotonin-syndrome\/symptoms-causes\/syc-20354758\" target=\"_blank\" rel=\"noopener\">https:\/\/www.mayoclinic.org\/diseases-conditions\/serotonin-syndrome\/symptoms-causes\/syc-20354758<\/a><\/p>\n\n\n\n<p>Kelly A. Cochran, Larisa H. Cavallari, Nancy L. Shapiro, Jeffrey R. Bishop. \u201cBleeding Incidence with Concomittant Use of Antidepressants and Warfarin\u201d <em>National Library of Medicine<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3212440\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3212440\/<\/a><\/p>\n\n\n\n<p>Patricia Weisser. \u201cImipramine (Tofranil): dosage, uses, side effects\u201d <em>ro<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/ro.co\/health-guide\/imipramine-tofranil-dosage-uses-side-effects\/\" target=\"_blank\" rel=\"noopener\">https:\/\/ro.co\/health-guide\/imipramine-tofranil-dosage-uses-side-effects\/<\/a><\/p>\n\n\n\n<p>\u201cCompare Tofranil-PM vs. doxepin\u201d <em>Iodine<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/www.iodine.com\/compare\/tofranil-pm-vs-doxepin\" target=\"_blank\" rel=\"noopener\">https:\/\/www.iodine.com\/compare\/tofranil-pm-vs-doxepin<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>In this article, we\u2019ll review doxepin and Tofranil, two medications that can help treat major depressive disorder. Armed with this new knowledge, you\u2019ll be able to advocate for yourself and have an informed discussion with your mental health provider.<\/p>\n","protected":false},"author":29,"featured_media":6939,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[75],"temp_settings":[116],"_links":{"self":[{"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/posts\/6938"}],"collection":[{"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/comments?post=6938"}],"version-history":[{"count":11,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/posts\/6938\/revisions"}],"predecessor-version":[{"id":18292,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/posts\/6938\/revisions\/18292"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/media\/6939"}],"wp:attachment":[{"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/media?parent=6938"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/categories?post=6938"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/tags?post=6938"},{"taxonomy":"temp_settings","embeddable":true,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/temp_settings?post=6938"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}