{"id":5655,"date":"2022-11-09T13:49:55","date_gmt":"2022-11-09T21:49:55","guid":{"rendered":"https:\/\/cms.helloklarity.com\/?p=5655"},"modified":"2024-02-12T09:00:13","modified_gmt":"2024-02-12T17:00:13","slug":"prozac-vs-celexa","status":"publish","type":"post","link":"https:\/\/cms.helloklarity.com\/post\/prozac-vs-celexa\/","title":{"rendered":"Prozac vs. Celexa"},"content":{"rendered":"\n

Prozac and Celexa are two of the most common medications used to treat anxiety and depression. Although these medications are similar, there are key differences between the two that should be considered before starting a new medication. <\/p>\n\n\n\n

In this article, we will give a full comparison guide of Prozac and Celexa so that you can have a more informed discussion with a healthcare provider about which medication is right for you. <\/p>\n\n\n\n

When searching for the right medication for you, always consult with a medical professional to discuss your symptoms, potential side effects, and contraindications with other drugs. If you need an affordable, reliable healthcare provider, Klarity can help. We\u2019ll connect you with a licensed provider in your state for online depression<\/a> or anxiety treatment<\/a>.<\/p>\n\n\n\n

When you work with a provider on Klarity, you can receive an evaluation, diagnosis, and treatment for your symptoms, if applicable, in just 48 hours. Your provider can also help you determine if Prozac, Celexa, or another form of medication is right for you, and send any prescriptions directly to your local pharmacy. To finally experience relief from your symptoms, schedule an appointment today<\/a>. <\/p>\n\n\n\n

This article discusses suicide, suicidal ideation, and self-harm. If you or someone you know is experiencing suicidal thoughts or is in crisis, contact the Suicide Prevention Lifeline immediately by dialing 988.<\/em><\/p>\n\n\n\n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t
<\/th>Celexa<\/th>Prozac<\/th>\n<\/tr>\n<\/thead>\n
Drug Class<\/strong><\/td>Selective serotonin reuptake inhibitor (SSRI)<\/td>Selective serotonin reuptake inhibitor (SSRI)<\/td>\n<\/tr>\n
Brand \/ Generic Status<\/strong><\/td>Brand name for citalopram<\/td>Brand name fluoxetine<\/td>\n<\/tr>\n
Form(s) of the Drug<\/strong><\/td>\u2022 Oval capsules
\r\n\u2022 Round tablets
\r\n\u2022 Clear, peppermint-flavored liquid suspension
\r\n<\/td>		\u2022 Clear, peppermint-flavored liquid suspension
\n\u2022 Half-green, half-white capsules
\n<\/td>\n<\/tr>\n
Standard Dosage<\/strong><\/td>Capsules:
\r\n\u2022 30mg dose
\r\n
\r\nTablets:
\r\n\u2022 10 mg
\r\n\u2022 20 mg
\r\n\u2022 40 mg
\r\n
\r\nLiquid suspension:
\r\n\u2022 10mg of citalopram per dose
\r\n
\r\n<\/td>		Liquid suspension:
\n\u2022 10mg per dose
\n
\nCapsules:
\n\u2022 10mg per dose
\n<\/td>\n<\/tr>\n
Conditions Treated<\/strong><\/td>FDA-approved uses:
\r\n\u2022 Major depressive disorder (MDD)
\r\n
\r\nOff-label uses:
\r\n\u2022 Obsessive-compulsive disorder (OCD)
\r\n\u2022 Binge eating disorder
\r\n\u2022 Alcohol use disorder
\r\n\u2022 Generalized anxiety disorder
\r\n\u2022 Panic disorder or PTSD
\r\n\u2022 Premenstrual dysphoric disorder
\r\n\u2022 Postmenopausal flushing
\r\n\u2022 Premature ejaculation
\r\n<\/td>		FDA-approved uses:
\n\u2022 Anxiety and stress
\n\u2022 Major depression
\n\u2022 Bulimia nervosa
\n\u2022 Premenstrual dysphoric disorder (PMDD)
\n\u2022 Obsessive-compulsive disorder (OCD)
\n\u2022 Panic disorder
\n\u2022 Postpartum depression
\n\u2022 Schizoaffective disorder
\n
\nOff-label uses:
\n\u2022 Anorexia nervosa
\n\u2022 Premature ejaculation
\n\u2022 Various anxiety disorders
\n<\/td>\n<\/tr>\n
Cost<\/strong><\/td>Brand-name:
\r\n\u2022 $4 for 30-day supply*
\r\n
\r\n*With coupon codes or insurance
\r\n<\/td>		Generic form (fluoxetine):
\n\u2022 $3 to $4 for 30-days\u2019 worth of capsules*
\n\u2022 $12 for 30 days\u2019 worth of liquid suspension
\n
\n*May cost up to $100 for high dosages
\n
\nBrand-name:
\n\u2022 $460 to $1000 for 30 days\u2019 worth of capsules<\/td>\n<\/tr>\n
Side-Effects<\/strong><\/td>Common side effects:
\r\n\u2022 Nausea or GI upset
\r\n\u2022 Dry mouth
\r\n\u2022 Changes in appetite
\r\n\u2022 Drowsiness or fatigue
\r\n\u2022 Increased sweating
\r\n\u2022 Blurred vision
\r\n
\r\nSerious side effects:
\r\n\u2022 Worsening depression
\r\n\u2022 Suicidal ideation
\r\n\u2022 Serotonin syndrome
\r\n\u2022 Rapid heart rate and high blood pressure
\r\n\u2022 High fever, resulting in increased sweating, shivering, or goosebumps
\r\n\u2022 Irregular heartbeat or palpitations
\r\n\u2022 Agitation or restlessness
\r\n\u2022 Loss of muscle coordination or uncontrollable muscle twitching or rigidity
\r\n\u2022 Diarrhea
\r\n\u2022 Headache
\r\n\u2022 Dilated pupils
\r\n\u2022 Confusion or altered consciousness
\r\n
\r\n<\/td>		Common side effects:
\n\u2022 Nausea
\n\u2022 Diarrhea or constipation
\n\u2022 Changes in appetite
\n\u2022 Headache and fatigue
\n\u2022 Increased sweating
\n\u2022 Trouble sleeping
\n\u2022 Impotence\/sexual dysfunction
\n
\nSerious side effects include:
\n\u2022 Fever
\n\u2022 High blood pressure
\n\u2022 Rigid muscles
\n\u2022 Seizures
\n\u2022 Kidney or respiratory failure
\n\u2022 Disorientation or delirium
\n\u2022 Serotonin syndrome
\n<\/td>\n<\/tr>\n
Warnings For Use<\/strong><\/td>Adverse drug reactions:
\r\n\u2022 MDMA
\r\n\u2022 St. John's Wort
\r\n\u2022 ADHD medications, such as Adderall
\r\n\u2022 Antipsychotic medications
\r\n\u2022 Tricyclic antidepressants
\r\n\u2022 Buspar
\r\n\u2022 Some migraine medications
\r\n\u2022 Lithium
\r\n\u2022 Antiplatelet and anticoagulant medications
\r\n\u2022 MAOIs
\r\n\u2022 Drugs that affect heart rhythm
\r\n
\r\n<\/td>		Contraindicated conditions:
\n\u2022 Diabetes
\n\u2022 Liver disease
\n\u2022 Alcohol use disorder
\n\u2022 History of bipolar disorder
\n\u2022 History of suicide attempts
\n\u2022 Low blood sodium or dehydration
\n\u2022 Seizures
\n\u2022 Gastrointestinal ulcers
\n\u2022 Glaucoma
\n
\nDrug Interactions:
\n\u2022 Monoamine oxidase inhibitors (MAOIs)
\n\u2022 Nonsteroidal anti-inflammatory drugs (NSAIDs)
\n\u2022 Aspirin and other blood thinners
\n\u2022 Antihistamines
\n\u2022 Opioid pain relievers
\n\u2022 St. John\u2019s wort
\n\u2022 Cannabis and MDMA
\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n

What is Prozac?<\/h2>\n\n\n\n

Prozac belongs to the class of medications called selective serotonin reuptake inhibitors (SSRIs), and is one of the most commonly prescribed medications for treating anxiety and depression. SSRIs work by increasing the levels of a neurotransmitter called serotonin. <\/p>\n\n\n\n

Those who suffer from anxiety and depression tend to have lower serotonin levels in the brain, and SSRI medications help restore this neurochemical imbalance.   <\/p>\n\n\n\n

Common doses and forms of Prozac<\/h3>\n\n\n\n

Prozac is available in a few different forms, including an oral solution, tablet, and capsule. The dose is typically started around 20 mg and can then be gradually titrated up weekly. The maximum dose should not exceed 80 mg per day. <\/p>\n\n\n\n

Capsules are available as <\/p>\n\n\n\n

    \n
  • 10 mg <\/li>\n\n\n\n
  • 20 mg <\/li>\n\n\n\n
  • 40 mg <\/li>\n\n\n\n
  • 90 mg delayed release <\/li>\n<\/ul>\n\n\n\n

    Tablets are available in the following dosage forms: <\/p>\n\n\n\n

      \n
    • 10 mg <\/li>\n\n\n\n
    • 20 mg <\/li>\n\n\n\n
    • 60 mg <\/li>\n<\/ul>\n\n\n\n

      The oral solution is the least commonly prescribed form and is typically reserved for use in the pediatric population. It is available in one strength of 20 mg\/5 mL. <\/p>\n\n\n\n

      Conditions Prozac treats<\/h3>\n\n\n\n

      Prozac is one of the most effective medications for treating several types of anxiety and depressive disorders. <\/p>\n\n\n\n

      Prozac is FDA-approved for: <\/p>\n\n\n\n

        \n
      • Major depressive disorder (MDD) <\/li>\n\n\n\n
      • Obsessive-compulsive disorder (OCD) <\/li>\n\n\n\n
      • Eating disorders, such as Bulimia nervosa <\/li>\n\n\n\n
      • Panic disorder <\/li>\n\n\n\n
      • Premenstrual dysphoric disorder (PMDD)<\/li>\n<\/ul>\n\n\n\n

        In addition, when used in combination with Zyprexa, Prozac is useful in the treatment of: <\/p>\n\n\n\n

          \n
        • Acute depressive disorders in patients with bipolar I disorder <\/li>\n\n\n\n
        • Treatment-resistant depression <\/li>\n<\/ul>\n\n\n\n

          Prozac can treat symptoms of Anxiety and Depression<\/h4>\n\n\n\n

          Prozac has been shown to improve mood and increase energy levels, which are commonly seen in people with depression. In addition, Prozac helps stabilize your mood and reduce feelings of helplessness and hopelessness. <\/p>\n\n\n\n

          Prozac is also effective in treating anxiety by decreasing the constant feelings of nervousness, restlessness, or worry. With continued long-term use of this medication, feelings of anxiety associated with social situations and ruminating or intrusive thoughts tend to lessen over time. <\/p>\n\n\n\n

          Off-label uses for Prozac<\/h4>\n\n\n\n

          The term \u201coff-label\u201d is used to describe any use of the medication that is not FDA-approved. This does not mean that it is ineffective in treating the following conditions, but it simply has not had dedicated clinical trials with the FDA for the specific use. <\/p>\n\n\n\n

          Some off-label uses include <\/p>\n\n\n\n

            \n
          • Generalized anxiety disorder <\/li>\n\n\n\n
          • Migraine headaches <\/li>\n\n\n\n
          • Fibromyalgia <\/li>\n\n\n\n
          • Neuropathy or nerve pain caused by long-term diabetes <\/li>\n\n\n\n
          • Premature ejaculation <\/li>\n<\/ul>\n\n\n\n

            Prozac Costs<\/h3>\n\n\n\n

            Prozac is available in name brand and generic form, called fluoxetine. Most commercial health insurance plans typically cover both formularies. Without insurance, a 30-day supply of name-brand Prozac can cost anywhere between $500-1000 a month, depending on the dosage. <\/p>\n\n\n\n

            With the use of coupon codes and generic formularies, an average monthly supply costs around $10. Coupon codes are available at all major pharmacies for those who do not have health insurance coverage. <\/p>\n\n\n\n

            Prozac Side Effects<\/h3>\n\n\n\n

            As with any medication, there is a possibility of experiencing side effects when starting a new medication. Although serious side effects are rare, it is important to take note of changes in your body and discuss them with your healthcare provider. <\/p>\n\n\n\n

            As with most SSRI medications, there are a number of potential mild side effects that may occur when initially starting the medication. These effects tend to lessen with long-term use. <\/p>\n\n\n\n

            Some of the most common side effects associated with Prozac include <\/p>\n\n\n\n

              \n
            • Difficulty falling asleep or insomnia <\/li>\n\n\n\n
            • Drowsiness or fatigue <\/li>\n\n\n\n
            • Changes in bowel movements, including diarrhea or constipation<\/li>\n\n\n\n
            • Changes in appetite<\/li>\n\n\n\n
            • Headache <\/li>\n\n\n\n
            • Increased anxiety or nervousness <\/li>\n\n\n\n
            • Tremor <\/li>\n\n\n\n
            • Dry mouth <\/li>\n\n\n\n
            • Sexual dysfunction, including lack of desire and orgasm <\/li>\n<\/ul>\n\n\n\n

              Prozac Warnings<\/h3>\n\n\n\n

              There are a few rare but serious side effects associated with taking Prozac, and therefore, the medication should be taken under close supervision when starting and stopping this medication. It is important to take Prozac as prescribed and to contact your healthcare provider if you begin to experience any of the following serious side effects. <\/p>\n\n\n\n

              Suicidal thoughts and behaviors<\/h4>\n\n\n\n

              In young adults under the age of 24, there is a risk that Prozac may worsen your depressive symptoms and may even result in new or increased suicidal ideation or behaviors. <\/p>\n\n\n\n

              If you begin to experience thoughts of self-harm, contact your healthcare provider immediately or seek urgent medical care at the nearest ER. The Suicide and Crisis Lifeline is available 24\/7 at 988. <\/p>\n\n\n\n

              Serotonin Syndrome<\/h4>\n\n\n\n

              Serotonin Syndrome is another rare but potentially fatal health condition that results from an overload of serotonin in the body. This is most commonly seen in people who are taking multiple medications that increase the levels of serotonin. <\/p>\n\n\n\n

              Common signs and symptoms of serotonin syndrome include: <\/p>\n\n\n\n

                \n
              • Fever<\/li>\n\n\n\n
              • High blood pressure<\/li>\n\n\n\n
              • Increased heart rate or irregular heartbeat <\/li>\n\n\n\n
              • Agitation or restlessness<\/li>\n\n\n\n
              • Diarrhea <\/li>\n\n\n\n
              • Dilated pupils <\/li>\n\n\n\n
              • Muscle spasms, stiffness, or loss of muscle coordination<\/li>\n\n\n\n
              • Confusion, or even coma <\/li>\n<\/ul>\n\n\n\n

                Withdrawal or Discontinuation Syndrome<\/h4>\n\n\n\n

                If you are considering discontinuing Prozac, it is important to discuss this with your healthcare provider so that you can be titrated off of the medication and avoid unwanted adverse effects from sudden withdrawal or discontinuation of the medication. <\/p>\n\n\n\n

                Common withdrawal symptoms include:<\/p>\n\n\n\n

                  \n
                • Dizziness or vertigo<\/li>\n\n\n\n
                • Headache <\/li>\n\n\n\n
                • Fatigue  <\/li>\n\n\n\n
                • Tremor or visual disturbances <\/li>\n\n\n\n
                • Nausea, vomiting, diarrhea <\/li>\n\n\n\n
                • Increased anxiety or agitation <\/li>\n\n\n\n
                • Confusion or irritability <\/li>\n\n\n\n
                • Insomnia <\/li>\n<\/ul>\n\n\n\n

                  Caution in Use with Elderly Patients<\/h4>\n\n\n\n

                  SSRI medications, including Prozac, should be used with caution in the older population due to additional potential health complications, including low blood pressure and electrolyte imbalances, which could result in increased falls.<\/p>\n\n\n\n

                  Prozac drug interactions<\/h3>\n\n\n\n

                  SSRI medications are relatively safe medications but are known to have potential interactions with other medications or over-the-counter supplements. Before starting any new medication, it is important to disclose all medications you are taking with your healthcare provider. <\/p>\n\n\n\n

                  Some common medications to avoid while taking Prozac include: <\/p>\n\n\n\n

                    \n
                  • Monoamines oxidase inhibitors<\/li>\n\n\n\n
                  • NSAIDs<\/li>\n\n\n\n
                  • Blood thinning medications, including Warfarin and aspirin<\/li>\n\n\n\n
                  • Opioids <\/li>\n\n\n\n
                  • Anti-nausea medications, including Zofran <\/li>\n\n\n\n
                  • Thiazide diuretics <\/li>\n\n\n\n
                  • Medications that increase serotonin levels: ADHD medications including Adderall, TCAs, Buspar, antipsychotics, Lithium, migraine medications, over-the-counter supplements such as St. John\u2019s Wort and recreational drugs like MDMA <\/li>\n<\/ul>\n\n\n\n

                    What is Celexa?<\/h2>\n\n\n\n

                    Similar to Prozac, Celexa is an SSRI medication that works by increasing serotonin levels in the brain. Celexa is commonly prescribed for depression and anxiety. Of note, Celexa is likely not the best treatment option for those who have chronic heart or liver problems. <\/p>\n\n\n\n

                    Common doses and forms of Celexa<\/h3>\n\n\n\n

                    Celexa is available in capsule, tablet, and oral solution forms. The tablet form is most commonly used in the adult population due to the various forms of dosing available. Celexa is typically started at 10 mg by mouth daily and can be titrated up by 10 mg weekly, as needed. <\/p>\n\n\n\n

                    The maximum dose is 40 mg per day, and in patients over 60 years of age, the maximum dose is 20 mg per day due to cardiac concerns in this population. <\/p>\n\n\n\n

                    Celexa is available in tablet form in the following doses: <\/p>\n\n\n\n

                      \n
                    • 10 mg <\/li>\n\n\n\n
                    • 20 mg <\/li>\n\n\n\n
                    • 40 mg <\/li>\n<\/ul>\n\n\n\n

                      Celexa capsules are available in 30 mg doses only. <\/p>\n\n\n\n

                      Like Prozac, the oral solution of Celexa is available in one dose of  10 mg\/5 mL and is typically reserved for the pediatric population. <\/p>\n\n\n\n

                      Conditions Celexa treats<\/h3>\n\n\n\n

                      Celexa is used in the treatment of several different depressive and anxiety disorders. The FDA has only formally approved the medication to treat major depressive disorder (MDD), but there are a number of off-label uses for this SSRI medication listed below.  <\/p>\n\n\n\n

                      Celexa can treat symptoms of Anxiety and Depression<\/h4>\n\n\n\n

                      Celexa is used to treat depression by improving mood and increasing the patient’s ability to enjoy everyday life activities that they once enjoyed. <\/p>\n\n\n\n

                      Additionally, Celexa can improve sleep disturbances and improve appetite, as well as calm the thought process, including anxious, restless, or intrusive thoughts associated with various anxiety disorders. <\/p>\n\n\n\n

                      Off-label uses for Celexa<\/h4>\n\n\n\n

                      As previously stated, the term \u201coff-label\u201d is used for any use of a medication that is not FDA approved for the medication. There are a number of \u201coff-label\u201d uses for Celexa, including:<\/p>\n\n\n\n

                        \n
                      • Obsessive-Compulsive Disorder (OCD)<\/li>\n\n\n\n
                      • Binge eating disorder <\/li>\n\n\n\n
                      • Alcohol use disorder <\/li>\n\n\n\n
                      • Generalized anxiety disorder <\/li>\n\n\n\n
                      • Panic disorder or PTSD<\/li>\n\n\n\n
                      • Premenstrual dysphoric disorder <\/li>\n\n\n\n
                      • Postmenopausal flushing <\/li>\n\n\n\n
                      • Premature ejaculation <\/li>\n<\/ul>\n\n\n\n

                        Celexa Costs<\/h3>\n\n\n\n

                        When compared to Prozac, Celexa is less expensive, with the average cost of a 30-day supply being roughly around $300-500 for name-brand Celexa without insurance. But when using a generic formulary and coupon codes, a 30-day supply is affordable at around $4. Most insurance plans typically cover Celexa, and prescription coupon codes are widely available at any major pharmacy. <\/p>\n\n\n\n

                        Celexa side effects<\/h3>\n\n\n\n

                        Prozac and Celexa have similar side effects because they belong to the same class of drugs and have the same mechanism of action on serotonin receptors in the brain. <\/p>\n\n\n\n

                        Some common side effects seen with Celexa include: <\/p>\n\n\n\n

                          \n
                        • Nausea or GI upset<\/li>\n\n\n\n
                        • Dry mouth <\/li>\n\n\n\n
                        • Changes in appetite <\/li>\n\n\n\n
                        • Drowsiness or fatigue <\/li>\n\n\n\n
                        • Increased sweating <\/li>\n\n\n\n
                        • Blurred vision <\/li>\n<\/ul>\n\n\n\n

                          Celexa warnings<\/h3>\n\n\n\n

                          As with Prozac, there are a few rare but serious warnings to keep in mind when starting Celexa, including increased incidences of worsening depression and increased suicidal ideation. If you are having thoughts of suicide or self-harm behaviors, contact your healthcare provider immediately or go to the nearest emergency department. <\/p>\n\n\n\n

                          The national suicide hotline can be reached by dialing 988 and is available 24\/7.<\/p>\n\n\n\n

                          Serotonin syndrome is an uncommon but serious condition caused by elevated levels of serotonin in the brain. This is most commonly seen in patients who are taking multiple medications that work by increasing serotonin. <\/p>\n\n\n\n

                          It is important to contact your healthcare provider or seek medical care if you begin to experience the following side effects: <\/p>\n\n\n\n

                            \n
                          • Rapid heart rate and high blood pressure <\/li>\n\n\n\n
                          • High fever, resulting in increased sweating, shivering, or goosebumps <\/li>\n\n\n\n
                          • Irregular heartbeat or palpitations <\/li>\n\n\n\n
                          • Agitation or restlessness<\/li>\n\n\n\n
                          • Loss of muscle coordination or uncontrollable muscle twitching or rigidity <\/li>\n\n\n\n
                          • Diarrhea <\/li>\n\n\n\n
                          • Headache <\/li>\n\n\n\n
                          • Dilated pupils <\/li>\n\n\n\n
                          • Confusion or altered consciousness<\/li>\n<\/ul>\n\n\n\n

                            Another important consideration with any SSRI is the potential for withdrawal syndrome. When considering discontinuing or decreasing the dose of your medication, it is important to discuss this plan with your healthcare provider so that they can guide the process and slowly titrate the medication. <\/p>\n\n\n\n

                            Celexa drug interactions<\/h3>\n\n\n\n

                            As with any medication, there are a number of associated drug interactions that may occur. It is important to discuss all current medications you are currently taking, including over-the-counter medications and supplements. <\/p>\n\n\n\n

                            Some medications that are known to interact with Celexa include <\/p>\n\n\n\n

                              \n
                            • Medications that increase the risk for serotonin syndrome:\n
                                \n
                              • Recreational drugs like MDMA or ecstasy <\/li>\n\n\n\n
                              • St. John’s Wort <\/li>\n\n\n\n
                              • ADHD medications, such as Adderall <\/li>\n\n\n\n
                              • Antipsychotic medications <\/li>\n\n\n\n
                              • Tricyclic antidepressants<\/li>\n\n\n\n
                              • Buspar <\/li>\n\n\n\n
                              • Some migraine medications, including sumatriptan, rizatriptan, tramadol <\/li>\n\n\n\n
                              • Lithium <\/li>\n<\/ul>\n<\/li>\n\n\n\n
                              • Antiplatelet and anticoagulant medications will increase the risk of bleeding<\/li>\n\n\n\n
                              • MAO inhibitors include linezolid, metaxalone, and methylene blue, to name a few. These medications should be discontinued two weeks before starting an SSRI.<\/li>\n<\/ul>\n\n\n\t\t
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