{"id":5573,"date":"2022-11-07T09:52:15","date_gmt":"2022-11-07T17:52:15","guid":{"rendered":"https:\/\/cms.helloklarity.com\/?p=5573"},"modified":"2023-12-20T11:53:13","modified_gmt":"2023-12-20T19:53:13","slug":"ssris-vs-snris","status":"publish","type":"post","link":"https:\/\/cms.helloklarity.com\/post\/ssris-vs-snris\/","title":{"rendered":"SSRIs vs. SNRIs: What Is the Difference and Which One Should I Take?"},"content":{"rendered":"\n<p>If you suffer from anxiety or depression, you\u2019ve probably heard about SSRIs and SNRIs.&nbsp;<\/p>\n\n\n\n<p>Though both drug types are clinically effective at treating <a href=\"https:\/\/www.klarityadhd.com\/post\/link-between-depression-and-anxiety\/\" data-type=\"link\" data-id=\"https:\/\/www.klarityadhd.com\/post\/link-between-depression-and-anxiety\/\" target=\"_blank\" rel=\"noopener\">depression and anxiety<\/a>, there are differences that might make one option more suitable for treating your particular symptoms.&nbsp;<\/p>\n\n\n\n<p>In this article, we\u2019ll discuss both types of antidepressants so you can better understand the pros and cons of each treatment.&nbsp;<\/p>\n\n\n\n<p>If you have anxiety or depression and are interested in treating your symptoms with an SSRI or SNRI antidepressants, make an appointment with a medical professional on Klarity today. Klarity connects you with a licensed healthcare provider in your state for convenient and affordable <a href=\"https:\/\/www.klarityadhd.com\/anxiety\/\" target=\"_blank\" rel=\"noopener\">online anxiety<\/a> and <a href=\"https:\/\/www.klarityadhd.com\/depression\/\" target=\"_blank\" rel=\"noopener\">depression treatment<\/a>, including a comprehensive evaluation, diagnosis, and prescription medication if applicable.<\/p>\n\n\n\n<p><a href=\"https:\/\/care.klarityadhd.com\/assessment\/get-started\" target=\"_blank\" rel=\"noopener\">Schedule your first private telehealth visit<\/a> on Klarity today and be seen by an anxiety or depression specialist in as little as 48 hours.&nbsp;<\/p>\n\n\n\n<p><em>This article discusses suicide, suicidal ideation, and self-harm. If you or someone you know is experiencing suicidal thoughts or is in crisis, contact the Suicide Prevention Lifeline immediately at 800-273-8255.<\/em><\/p>\n\n\n\n<table id=\"tablepress-40\" class=\"tablepress tablepress-id-40 tablepress-responsive\">\n<thead>\n<tr class=\"row-1 odd\">\n\t<th class=\"column-1\"><\/th><th class=\"column-2\">SSRIs<\/th><th class=\"column-3\">SNRIs<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-hover\">\n<tr class=\"row-2 even\">\n\t<td class=\"column-1\"><strong>Drug Class<\/strong><\/td><td class=\"column-2\">Selective serotonin reuptake inhibitors (SSRIs)<\/td><td class=\"column-3\">Selective serotonin and norepinephrine reuptake inhibitors (SNRIs)<\/td>\n<\/tr>\n<tr class=\"row-3 odd\">\n\t<td class=\"column-1\"><strong>Brand \/ Generic Status<\/strong><\/td><td class=\"column-2\">Brand-names and generics available<br \/>\n<br \/>\nMost common SSRIs:  <br \/>\n\u2022 Prozac (fluoxetine)<br \/>\n\u2022 Paxil (paroxetine)<br \/>\n\u2022 Zoloft (sertraline)<br \/>\n\u2022 Celexa (citalopram)<br \/>\n\u2022 Luvox (fluvoxamine)<br \/>\n\u2022 Lexapro (escitalopram)<br \/>\n\u2022 Trintellix (vortioxetine)<br \/>\n\u2022 Viibryd (vilazodone)<br \/>\n<\/td><td class=\"column-3\">Brand names and generics available<br \/>\n<br \/>\nMost common SNRIs: <br \/>\n\u2022 Effexor (venlafaxine)<br \/>\n\u2022 Cymbalta (duloxetine)<br \/>\n\u2022 Irenka (duloxetine)<br \/>\n\u2022 Pristiq (desvenlafaxine)<br \/>\n\u2022 Khedezla (desvenlafaxine) <br \/>\n\u2022 Fetzima (levomilnacipran)<br \/>\n\u2022 Savella (milnacipran)<br \/>\n<br \/>\n<\/td>\n<\/tr>\n<tr class=\"row-4 even\">\n\t<td class=\"column-1\"><strong>Form(s) of the Drug<\/strong><\/td><td class=\"column-2\">Common forms of SSRIs include:<br \/>\n\u2022 Color-coded* capsules<br \/>\n\u2022 Color-coded* tablets<br \/>\n\u2022 Flavored liquid suspensions<br \/>\n<br \/>\n*Color-coding often indicates dosage amount<\/td><td class=\"column-3\">Common forms of SNRIs include: <br \/>\n\u2022 Color-coded* capsules<br \/>\n\u2022 Color-coded* tablets<br \/>\n\u2022 Flavored liquid suspensions<br \/>\n<br \/>\n*Color-coding often indicates dosage amount<\/td>\n<\/tr>\n<tr class=\"row-5 odd\">\n\t<td class=\"column-1\"><strong>Standard Dosage<\/strong><\/td><td class=\"column-2\">Varies, depending on SSRI and condition being treated<\/td><td class=\"column-3\">Varies, depending on SNRI and condition being treated<\/td>\n<\/tr>\n<tr class=\"row-6 even\">\n\t<td class=\"column-1\"><strong>Conditions Treated<\/strong><\/td><td class=\"column-2\">Conditions most often treated: <br \/>\n\u2022 Major depressive disorder<br \/>\n\u2022 Generalized anxiety disorder<br \/>\n<br \/>\nOther conditions treated: <br \/>\n\u2022 Obsessive-compulsive disorder (OCD)<br \/>\n\u2022 Eating disorders<br \/>\n\u2022 Premenstrual dysphoric disorder (PMDD)<br \/>\n<br \/>\nDifferent SSRIs are \u2022 FDA-approved for different uses<br \/>\n<br \/>\nMany SSRIs are prescribed off-label to treat certain conditions<br \/>\n<\/td><td class=\"column-3\">Conditions most often treated: <br \/>\n\u2022 Depression<br \/>\n\u2022 Anxiety disorders<br \/>\n<br \/>\nOther conditions treated: <br \/>\n\u2022 Attention deficit<br \/>\nhyperactivity disorder (ADHD)<br \/>\n<br \/>\n<br \/>\nDifferent SNRIs are FDA-approved for different uses<br \/>\n<br \/>\nMany SNRIs are prescribed off-label to treat certain conditions<br \/>\n<\/td>\n<\/tr>\n<tr class=\"row-7 odd\">\n\t<td class=\"column-1\"><strong>Cost<\/strong><\/td><td class=\"column-2\">Average cost of a 30-day supply:<br \/>\n\u2022 $4 to $40 for generic formulas*<br \/>\n\u2022 $130 or more for brand-name formulas**<br \/>\n<br \/>\n*Some SSRIs don\u2019t have a generic formula available for Rx.<br \/>\n<br \/>\n**Cost of brand-name SSRIs may be offset by coupons and insurance<br \/>\n<\/td><td class=\"column-3\">Average cost of a 30-day supply: <br \/>\n\u2022 $29 for generic formulas*<br \/>\n\u2022 $539 for brand-name formulas**<br \/>\n<br \/>\n*Some SNRIs don\u2019t have a generic formula available for Rx.<br \/>\n<br \/>\n**Cost of brand-name SNRIs may be offset by coupons and insurance<br \/>\n<br \/>\n<\/td>\n<\/tr>\n<tr class=\"row-8 even\">\n\t<td class=\"column-1\"><strong>Side-Effects<\/strong><\/td><td class=\"column-2\">Common side effects:<br \/>\n\u2022 Nausea, vomiting, GI upset, or diarrhea<br \/>\n\u2022 Dry mouth <br \/>\n\u2022 Headache <br \/>\n\u2022 Difficulty sleeping or insomnia <br \/>\n\u2022 Drowsiness or dizziness <br \/>\n\u2022 Increased nervousness, feelings of restlessness, or agitation<br \/>\n\u2022 Reduced libido, erectile dysfunction <br \/>\n\u2022 Increase or decrease appetite, leading to changes in weight <br \/>\n<\/td><td class=\"column-3\">Common side effects: <br \/>\n\u2022 Increased blood pressure<br \/>\n\u2022 Increased heart rate<br \/>\n\u2022 Headache<br \/>\n\u2022 Difficulty urinating<br \/>\n\u2022 Nausea<br \/>\n\u2022 Eating too much or too little<br \/>\n\u2022 Dry mouth<br \/>\n\u2022 Excessive sweating<br \/>\n\u2022 Constipation<br \/>\n\u2022 Muscle weakness<br \/>\n\u2022 Tremors<br \/>\n\u2022 Irritability<br \/>\n\u2022 Heart palpitations<br \/>\n\u2022 Dizziness<br \/>\n\u2022 Insomnia<br \/>\n\u2022 Drowsiness<br \/>\n\u2022 Fluid retention, especially in older adults<br \/>\n\u2022 Inability to maintain an erection or have an orgasm<br \/>\n<\/td>\n<\/tr>\n<tr class=\"row-9 odd\">\n\t<td class=\"column-1\"><strong>Warnings For Use<\/strong><\/td><td class=\"column-2\">\u2022 Combination with other medications may cause serotonin syndrome<br \/>\n\u2022 Symptoms of serotonin syndrome include: <br \/>\n         \u2022 Anxiety or agitation<br \/>\n         \u2022 Fever, sweating<br \/>\n         \u2022 Tremors<br \/>\n         \u2022 Restlessness<br \/>\n         \u2022 Confusion<br \/>\n         \u2022 Lack of coordination<br \/>\n         \u2022 Blood pressure and heart rate changes<br \/>\n<br \/>\n\u2022 Rarely, SSRIs may cause <br \/>\nsuicidal thoughts or behaviors<br \/>\n         \u2022 Contact your doctor immediately if this occurs<br \/>\n<br \/>\n\u2022 Discuss other medications with your doctor, as adverse reactions may occur<br \/>\n<\/td><td class=\"column-3\">\u2022 Combination with other medications may cause serotonin syndrome<br \/>\n\u2022 Symptoms of serotonin syndrome include: <br \/>\n         \u2022 Anxiety or agitation<br \/>\n         \u2022 Fever, sweating<br \/>\n         \u2022 Tremors<br \/>\n         \u2022 Restlessness<br \/>\n         \u2022 Confusion<br \/>\n         \u2022 Lack of coordination<br \/>\n         \u2022 Blood pressure and heart rate changes<br \/>\n<br \/>\n\u2022 Contraindicated conditions include: <br \/>\n         \u2022 Pregnancy<br \/>\n         \u2022 Breastfeeding<br \/>\n         \u2022 Liver problems<br \/>\n         \u2022 Heart conditions<br \/>\n<br \/>\n\u2022 Discuss other medications with your doctor, as adverse reactions may occur<br \/>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-40 from cache -->\n\n\n\n<h2 class=\"wp-block-heading\">About SSRIs and SNRIs&nbsp;<\/h2>\n\n\n\n<p>SSRIs (selective serotonin reuptake inhibitors) and SNRIs (serotonin and norepinephrine reuptake inhibitors) have both been shown to be effective treatments for depression and anxiety.&nbsp;<\/p>\n\n\n\n<p>Both of these medications address chemical imbalances that cause both mental health conditions. Still, there are several differences that you need to understand before you can make an informed decision on which one is right for you.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">SSRIs (Selective Serotonin Reuptake Inhibitors)<\/h2>\n\n\n\n<p>SSRIs are one of the most commonly prescribed forms of antidepressants and have proven to be considerably effective at treating mild to severe depression symptoms. They are relatively safe, typically causing fewer side effects than other antidepressants.&nbsp;<\/p>\n\n\n\n<p>Medical providers often choose SSRIs like fluoxetine (Prozac), sertraline (Zoloft), and escitalopram (Cipralex) to treat depression.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">How Do SSRIs Work?<\/h3>\n\n\n\n<p>SSRIs work by altering how the brain uses the neurotransmitters serotonin and dopamine. The medication blocks the reabsorption of these neurotransmitters, making the concentration higher in the spaces between brain cells (neurons).&nbsp;<\/p>\n\n\n\n<p>When the concentration of neurotransmitters is brought back into balance, brain cells can communicate with one another more effectively.&nbsp;<\/p>\n\n\n\n<p>Serotonin is responsible for several important bodily functions, including:<\/p>\n\n\n\n<ul>\n<li>Mood<\/li>\n\n\n\n<li>Digestion<\/li>\n\n\n\n<li>Sleep<\/li>\n\n\n\n<li>Wound healing<\/li>\n\n\n\n<li>Sexual function<\/li>\n\n\n\n<li>Nausea<\/li>\n<\/ul>\n\n\n\n<p>Dopamine is responsible for other bodily functions, including:<\/p>\n\n\n\n<ul>\n<li>Memory<\/li>\n\n\n\n<li>Pleasure<\/li>\n\n\n\n<li>Learning<\/li>\n\n\n\n<li>Attention<\/li>\n\n\n\n<li>Motivation<\/li>\n<\/ul>\n\n\n\n<p>When these neurotransmitter levels are too low, it can cause certain symptoms of depression and anxiety. Because SSRIs elevate serotonin and dopamine levels over time, they are effective at treating symptoms of anxiety and depression.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What Do SSRIs Treat?<\/h3>\n\n\n\n<p>SSRIs are most commonly thought of as a depression treatment, but they can also be effective at treating other conditions, including anxiety, panic disorder, OCD, PTSD, and other mood disorders.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Depression<\/h4>\n\n\n\n<p>Depression (major depressive disorder or MDD) is a mood disorder that negatively affects how you think and feel, leading to emotions of sadness, apathy, and exhaustion. With MDD, these emotions severely impact your quality of life. If untreated, depression can lead to several physical, emotional, and behavioral problems.&nbsp;<\/p>\n\n\n\n<p>Depression symptoms include:<\/p>\n\n\n\n<ul>\n<li>Feeling sad or tearful<\/li>\n\n\n\n<li>Feeling empty and hopeless<\/li>\n\n\n\n<li>Feeling irritable and angry when there isn\u2019t an obvious trigger<\/li>\n\n\n\n<li>Feeling disinterested in hobbies or activities that used to bring joy<\/li>\n\n\n\n<li>Sleeping too much or too little<\/li>\n\n\n\n<li>Eating too much or too little<\/li>\n\n\n\n<li>Anxiety and restlessness&nbsp;<\/li>\n\n\n\n<li>Weight Loss or weight gain<\/li>\n\n\n\n<li>Trouble concentrating, thinking, and making decisions<\/li>\n\n\n\n<li>Feeling excessively tired<\/li>\n\n\n\n<li>Moving or speaking slowly<\/li>\n\n\n\n<li>Thoughts of suicide or self-harm<\/li>\n\n\n\n<li>Unexplainable physical aches and pains<\/li>\n<\/ul>\n\n\n\n<p>Many depression symptoms could be the result of serotonin and dopamine imbalances in the brain. Since SSRIs affect the neurotransmitters that control mood, motivation, sleep, and pleasure, elevating the number of these neurotransmitters can help reduce depression symptoms.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Anxiety Disorders<\/h4>\n\n\n\n<p>There are several anxiety disorders that SSRIs are approved to treat. Generally, people with anxiety experience persistent, intense, and distracting bouts of fear and worry over common situations.&nbsp;<\/p>\n\n\n\n<p>SSRIs are considered effective in treating the following anxiety disorders:<\/p>\n\n\n\n<ul>\n<li>Generalized Anxiety Disorder<\/li>\n\n\n\n<li>Panic Disorder<\/li>\n\n\n\n<li>Social Anxiety Disorder<\/li>\n\n\n\n<li>Post Traumatic Stress Disorder<\/li>\n\n\n\n<li>Obsessive-Compulsive Disorder<\/li>\n\n\n\n<li>Phobias<\/li>\n<\/ul>\n\n\n\n<p>Symptoms of anxiety include:<\/p>\n\n\n\n<ul>\n<li>Nervousness<\/li>\n\n\n\n<li>Restlessness<\/li>\n\n\n\n<li>Feeling a sense of impending danger, doom, or panic<\/li>\n\n\n\n<li>Increased heart rate<\/li>\n\n\n\n<li>Hyperventilation<\/li>\n\n\n\n<li>Sweating<\/li>\n\n\n\n<li>Shaking<\/li>\n\n\n\n<li>Insomnia<\/li>\n\n\n\n<li>Difficulty thinking about the present or tasks at hand (work, school, conversations) due to worry<\/li>\n\n\n\n<li>Rumination<\/li>\n\n\n\n<li>Inability to control thoughts and feelings of worry<\/li>\n\n\n\n<li>Exhaustion<\/li>\n\n\n\n<li>G.I. Difficulties<\/li>\n\n\n\n<li>Avoiding triggers that cause anxiety<\/li>\n<\/ul>\n\n\n\n<p>Many anxiety symptoms can be caused by an imbalance of serotonin and dopamine, since these neurotransmitters are responsible for regulating mood, feelings of well-being, sleep, motivation, and alertness. SSRIs provide a way to regulate the levels of serotonin and dopamine in the brain, reducing anxiety symptoms.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What Are the Most Commonly Prescribed SSRIs?<\/h3>\n\n\n\n<p>The FDA has approved numerous SSRIs for the treatment of depression and anxiety. Some medications are prescribed more often than others due to their effectiveness or limited side effects.&nbsp;<\/p>\n\n\n\n<p>A licensed healthcare provider will work with you to determine the best medication for your symptoms. Below are some of the most common SSRIs prescribed by medical providers.<\/p>\n\n\n\n<ul>\n<li>Zoloft (sertraline)&nbsp;<\/li>\n\n\n\n<li>Prozac (fluoxetine)<\/li>\n\n\n\n<li><a href=\"https:\/\/www.klarityadhd.com\/post\/prozac-vs-celexa\/\" data-type=\"link\" data-id=\"https:\/\/www.klarityadhd.com\/post\/prozac-vs-celexa\/\" target=\"_blank\" rel=\"noopener\">Celexa<\/a> (citalopram)<\/li>\n\n\n\n<li>Paxil (paroxetine)<\/li>\n\n\n\n<li>Lexapro (escitalopram)&nbsp;<\/li>\n\n\n\n<li>Luvox (fluvoxamine)<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Costs<\/h3>\n\n\n\n<p>SSRIs are relatively inexpensive, with Zoloft and Prozac often costing $40 for 30 tablets. The generic forms of these medications are significantly less expensive and more likely to be covered by insurance.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Common Side Effects<\/h3>\n\n\n\n<p>SSRIs may cause side effects. Some of the most common include:<\/p>\n\n\n\n<ul>\n<li>Agitation<\/li>\n\n\n\n<li>Irritability<\/li>\n\n\n\n<li>Anxiety<\/li>\n\n\n\n<li>Headaches<\/li>\n\n\n\n<li>Loss of appetite and weight loss<\/li>\n\n\n\n<li>Increased appetite and weight gain<\/li>\n\n\n\n<li>Diarrhea<\/li>\n\n\n\n<li>Constipation<\/li>\n\n\n\n<li>Dizziness<\/li>\n\n\n\n<li>Blurred vision<\/li>\n\n\n\n<li>Dry mouth<\/li>\n\n\n\n<li>Sweating<\/li>\n\n\n\n<li>Feeling too tired or not sleeping well<\/li>\n\n\n\n<li>Reduced sex drive<\/li>\n\n\n\n<li>Difficulty achieving orgasm<\/li>\n\n\n\n<li>Erectile dysfunction<\/li>\n<\/ul>\n\n\n\n<p>Some people may have an allergic reaction to certain SSRIs, so it\u2019s important to discuss your medical history with your psychiatric healthcare provider before taking these medications.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Warnings for Use<\/h3>\n\n\n\n<p>SSRIs are generally safe, but they pose some risks if misused or taken without following your healthcare provider\u2019s instructions. While SSRIs are typically <a href=\"https:\/\/www.klarityadhd.com\/post\/non-addictive-anxiety-medication-online\/\" data-type=\"link\" data-id=\"https:\/\/www.klarityadhd.com\/post\/non-addictive-anxiety-medication-online\/\" target=\"_blank\" rel=\"noopener\">non-addictive<\/a>, dependency can occur in some people.\u00a0<\/p>\n\n\n\n<p>SSRIs can also react negatively when taken with other medications, including:<\/p>\n\n\n\n<ul>\n<li>SNRIs&nbsp;<\/li>\n\n\n\n<li>Lithium, which treats severe depression and bipolar disorder<\/li>\n\n\n\n<li>Clozapine and pimozide, which are used to treat schizophrenia and psychosis<\/li>\n\n\n\n<li>Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen<\/li>\n\n\n\n<li>Some asthma medications, including theophylline\u2013a medicine used to treat asthma<\/li>\n\n\n\n<li>Some migraine medications<\/li>\n\n\n\n<li>Tricyclic antidepressants<\/li>\n\n\n\n<li>Monoamine oxidase inhibitors (MAOIs)<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Serotonin Syndrome<\/h4>\n\n\n\n<p>In rare cases, SSRIs can lead to <em>s<\/em>erotonin syndrome\u2014an excess buildup of serotonin in the brain. This disorder can occur when two medications that raise serotonin levels are taken simultaneously.&nbsp;<\/p>\n\n\n\n<p>Serotonin syndrome typically happens within a few hours of taking a medication that elevates serotonin levels. These symptoms can include anxiety, high fever, and confusion. Seek immediate medical attention if you show any of these symptoms directly after taking an antidepressant.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Suicidal Thoughts and Ideation<\/h4>\n\n\n\n<p>All antidepressants come with a <strong>black box warning<\/strong>. In certain placebo-controlled studies, children and adolescents taking antidepressants reported an increase in suicidal thoughts and ideation compared to the placebo group. Though these findings have not been replicated in adult populations, the FDA requires that issuers of antidepressants disclose these risks.<\/p>\n\n\n\t\t<div data-elementor-type=\"page\" data-elementor-id=\"15401\" class=\"elementor elementor-15401\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c521b1f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c521b1f\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1e5f769\" data-id=\"1e5f769\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-8537e6b elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8537e6b\" data-element_type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-f020c0d\" data-id=\"f020c0d\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2478e2a elementor-widget__width-auto elementor-widget elementor-widget-heading\" data-id=\"2478e2a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.19.0 - 07-02-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-large\">Licensed providers on Klarity provide personalized treatment. \nFind a provider that matches your needs and preferences.<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-87df69e elementor-widget elementor-widget-spacer\" data-id=\"87df69e\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.19.0 - 07-02-2024 *\/\n.elementor-column .elementor-spacer-inner{height:var(--spacer-size)}.e-con{--container-widget-width:100%}.e-con-inner>.elementor-widget-spacer,.e-con>.elementor-widget-spacer{width:var(--container-widget-width,var(--spacer-size));--align-self:var(--container-widget-align-self,initial);--flex-shrink:0}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container,.e-con>.elementor-widget-spacer>.elementor-widget-container{height:100%;width:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer{height:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner{height:var(--container-widget-height,var(--spacer-size))}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty,.e-con>.elementor-widget-spacer.elementor-widget-empty{position:relative;min-height:22px;min-width:22px}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon,.e-con>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon{position:absolute;top:0;bottom:0;left:0;right:0;margin:auto;padding:0;width:22px;height:22px}<\/style>\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-76f1234 elementor-widget-tablet__width-inherit elementor-tablet-align-center elementor-align-center elementor-widget__width-auto elementor-widget elementor-widget-button\" data-id=\"76f1234\" data-element_type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_on&quot;:[&quot;mobile&quot;],&quot;sticky_offset_mobile&quot;:0,&quot;sticky_effects_offset_mobile&quot;:0,&quot;sticky_offset&quot;:0,&quot;sticky_effects_offset&quot;:0}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/care.helloklarity.com\/assessment\/get-started?utm_source=blog&#038;utm_medium=cta&#038;utm_campaign=blue\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Find a provider<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t\n\n\n\n<h2 class=\"wp-block-heading\">SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors)<\/h2>\n\n\n\n<p>Selective serotonin-norepinephrine reuptake inhibitors&nbsp; (SNRIs) are similar to SSRIs in that they prevent the reuptake of certain neurotransmitters. However, there is a key difference\u2014SNRIs affect norepinephrine levels in addition to serotonin and dopamine levels.&nbsp;&nbsp;<\/p>\n\n\n\n<p>SNRIs effectively relieve many depression symptoms, and are also prescribed for certain anxiety disorders. Although, SNRIs may make anxiety worse for some people, so it\u2019s best to consult with your medical provider before and during treatment.&nbsp;&nbsp;&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">How Do SNRIs Work?<\/h3>\n\n\n\n<p>Norepinephrine has distinct functions in the human body. Not only is it a neurotransmitter, but it\u2019s also a hormone. It plays a crucial role in mediating your body\u2019s flight-or-fight response.&nbsp;<\/p>\n\n\n\n<p>Norepinephrine performs the following specific functions:&nbsp;<\/p>\n\n\n\n<ul>\n<li>Increases attention, alertness, and arousal&nbsp;<\/li>\n\n\n\n<li>Constricts blood vessels<\/li>\n\n\n\n<li>Regulates mood and memory<\/li>\n\n\n\n<li>Affects the body\u2019s sleep cycles<\/li>\n<\/ul>\n\n\n\n<p>Norepinephrine has an important role in moderating memory, mood, alertness, and attention. Low levels of norepinephrine are associated with certain symptoms of depression and anxiety.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What Do SNRIs Treat?<\/h3>\n\n\n\n<p>SNRIs are primarily used to treat depression and anxiety disorders. However, there are off-label applications as well.&nbsp;&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Depression<\/h4>\n\n\n\n<p>SNRIs are mainly prescribed as a depression treatment due to their effects on serotonin and norepinephrine. While serotonin contributes to a general sense of well-being, norepinephrine increases energy levels, arousal, and alertness.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Anxiety<\/h4>\n\n\n\n<p>SNRIs can also treat anxiety disorders; however,<em> they don\u2019t work for everybody<\/em>. While increased serotonin levels can help improve anxiety symptoms, increased norepinephrine levels can have the opposite effect and make someone feel even more nervous.&nbsp;<\/p>\n\n\n\n<p>This is because of norepinephrine\u2019s ability to heighten alertness and blood pressure, which may negatively impact some people with anxiety.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Off-Label Treatment for ADHD<\/h4>\n\n\n\n<p>Certain SNRIs are used as an off-label treatment for managing ADHD symptoms. While CNS stimulants are the first-line treatment for managing symptoms of ADHD, SNRIs can also be effective due to their impact on norepinephrine, which regulates attention, focus, and memory.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What Are the Most Commonly Prescribed SNRIs?<\/h3>\n\n\n\n<p>SNRIs have been on the market since the mid-1990s. Currently, there are seven SNRI brands available in the US:<\/p>\n\n\n\n<ul>\n<li>Effexor (venlafaxine)<\/li>\n\n\n\n<li>Cymbalta (duloxetine)<\/li>\n\n\n\n<li>Irenka (duloxetine)<\/li>\n\n\n\n<li>Pristiq (desvenlafaxine)<\/li>\n\n\n\n<li>Khedezla (desvenlafaxine)&nbsp;<\/li>\n\n\n\n<li>Fetzima (Levomilnacipran)<\/li>\n\n\n\n<li>Savella (milnacipran)<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Costs<\/h3>\n\n\n\n<p>The cost of SNRIs is less consistent than SSRIs, but they are mostly inexpensive. 30 capsules of venlafaxine (generic Effexor), for example, can cost as little as $29, but other medications can be much more expensive.&nbsp;<\/p>\n\n\n\n<p>The lowest price of Fetzima, which is not available in generic form, is about $539 for 30 capsules, making it dramatically more expensive than any other available antidepressant.<\/p>\n\n\n\n<p>Typically, most insurance plans cover generic medications. Check with your carrier to discuss your coverage. If a prescription is not covered, your healthcare provider or the manufacturer may be able to provide coupons to help cut the cost.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Common SNRI Side Effects<\/h3>\n\n\n\n<p>SNRIs are considered safe, but they do have some (often temporary) side effects, including:<\/p>\n\n\n\n<ul>\n<li>High blood pressure<\/li>\n\n\n\n<li>Increased heart rate<\/li>\n\n\n\n<li>Headache<\/li>\n\n\n\n<li>Difficulty urinating<\/li>\n\n\n\n<li>Nausea<\/li>\n\n\n\n<li>Eating too much or too little<\/li>\n\n\n\n<li>Dry mouth<\/li>\n\n\n\n<li>Excessive sweating<\/li>\n\n\n\n<li>Constipation<\/li>\n\n\n\n<li>Muscle weakness<\/li>\n\n\n\n<li>Tremors<\/li>\n\n\n\n<li>Irritability<\/li>\n\n\n\n<li>Heart palpitations<\/li>\n\n\n\n<li>Dizziness<\/li>\n\n\n\n<li>Insomnia<\/li>\n\n\n\n<li>Drowsiness<\/li>\n\n\n\n<li>Fluid retention, especially in older adults<\/li>\n\n\n\n<li>Inability to maintain an erection or have an orgasm (in men)<\/li>\n<\/ul>\n\n\n\n<p>In rare cases, SNRIs may cause serious side effects, such as bruising or muscle cramps. If you experience severe side effects, contact your healthcare provider right away.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">SNRI Warnings for Use<\/h3>\n\n\n\n<p>Though SNRIs are considered safe, people with certain health conditions should avoid them.&nbsp;<\/p>\n\n\n\n<p>People who are pregnant or breastfeeding should not use SNRIs unless it\u2019s deemed medically necessary. If taking SNRIs for the second half of pregnancy, the baby might develop SNRI withdrawal symptoms, including tremors, feeding issues, and breathing difficulties.<\/p>\n\n\n\n<p>People with liver problems should consult a doctor before starting treatment on SNRIs. SNRIs are metabolized by the liver and will put extra strain on it.<\/p>\n\n\n\n<p>Norepinephrine raises blood pressure in a way that may cause cardiovascular issues for people with hypertension. People who have hypertension should consult with a doctor before starting SNRIs.&nbsp;<\/p>\n\n\n\n<p>You should never stop taking any SNRI without guidance from your medical provider, as withdrawal symptoms may occur.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Serotonin Syndrome<\/h4>\n\n\n\n<p>A rare condition called serotonin syndrome can also occur with SNRIs. If you experience any of the following symptoms, immediately contact emergency health services:<\/p>\n\n\n\n<ul>\n<li>Anxiety, agitation, confusion, or restlessness<\/li>\n\n\n\n<li>Severe sweating<\/li>\n\n\n\n<li>Tremors<\/li>\n\n\n\n<li>Lack of coordination<\/li>\n\n\n\n<li>Rapid heart rate<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Black Box Warning<\/h4>\n\n\n\n<p>All antidepressants, SNRIs included, come with the same <strong>black box warning<\/strong> that SSRIs have.&nbsp; Based on certain placebo-controlled studies, children and adolescents in the trial reported an increase in suicidal thoughts and ideation compared to the placebo group.&nbsp;<\/p>\n\n\n\n<p>These findings have not been replicated in adult populations. However, the FDA requires that these risks be disclosed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">SSRIs or SNRIs: Which Medication Is Right For You?<\/h2>\n\n\n\n<p>Finding the right depression treatment takes time. In general, SSRIs are the first-line treatment for depression and are also effective when treating anxiety symptoms. However, based on your needs, medical history, and toleration of the side effects, SSRIs might not be the best option for you.<\/p>\n\n\n\n<p>SNRIs help elevate norepinephrine levels in addition to serotonin and dopamine levels. Norepinephrine has different effects on the body, which makes SNRIs an alternative for people who don\u2019t respond well to SSRIs.&nbsp;<\/p>\n\n\n\n<p>People with ADHD and comorbid depression might benefit from SNRIs because of norepinephrine&#8217;s role in moderating alertness, attention, concentration, and mood.<\/p>\n\n\n\n<p>Ultimately, finding the right medication for you requires the knowledge and assistance of a licensed medical professional specializing in depression and anxiety. If you need <a href=\"https:\/\/www.klarityadhd.com\/treatment\/\" target=\"_blank\" rel=\"noopener\">affordable, simple psychiatric treatment<\/a>, Klarity can help.<\/p>\n\n\n\n<p>Klarity has helped thousands of Americans find online depression and anxiety treatment through convenient, private, insurance-free telemedicine services. We\u2019ll connect you with a board-certified mental health specialist who can diagnose your symptoms and prescribe the safest and most effective antidepressant for you if they determine it the best option for you.<\/p>\n\n\n\n<p>To get started with Klarity, <a href=\"https:\/\/care.klarityadhd.com\/assessment\/get-started\" target=\"_blank\" rel=\"noopener\">schedule an appointment<\/a>. Within 48 hours, you can begin treatment and receive a prescription for an SSRI or SNRI that will be sent directly to your local pharmacy, if applicable.&nbsp;<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-layout-1 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>Sources<\/p>\n\n\n\n<p>Dharminder Singh; Abdolreza Saadabadi. \u201cVenlafaxine.\u201d <em>StatPearls<\/em>.&nbsp; <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK535363\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK535363\/<\/a><\/p>\n\n\n\n<p>Debra Fulghum Bruce, PhD. \u201cWhat Is Depression?\u201d <em>WebMD<\/em>. <a href=\"https:\/\/www.webmd.com\/depression\/guide\/detecting-depression\" target=\"_blank\" rel=\"noopener\">https:\/\/www.webmd.com\/depression\/guide\/detecting-depression<\/a><\/p>\n\n\n\n<p>\u201cDopamine.\u201d <em>Cleveland Clinic<\/em>. <a href=\"https:\/\/my.clevelandclinic.org\/health\/articles\/22581-dopamine\" target=\"_blank\" rel=\"noopener\">https:\/\/my.clevelandclinic.org\/health\/articles\/22581-dopamine<\/a><\/p>\n\n\n\n<p>Giovanni B. Cassano, MD; Nicol\u00f2 Baldini Rossi, MD; Stefano Pini, MD. \u201cPsychopharmacology of anxiety disorders.\u201d Dialogues Clin Neurosci. 2002 Sep; 4(3): 271\u2013285. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3181684\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3181684\/<\/a><\/p>\n\n\n\n<p>\u201cNorepinephrine (Noradrenaline).\u201d <em>Cleveland Clinic<\/em>. <a href=\"https:\/\/my.clevelandclinic.org\/health\/articles\/22610-norepinephrine-noradrenaline\" target=\"_blank\" rel=\"noopener\">https:\/\/my.clevelandclinic.org\/health\/articles\/22610-norepinephrine-noradrenaline<\/a><\/p>\n\n\n\n<p>Jennifer Fink. \u201cSerotonin-Norepinephrine Reuptake Inhibitors (SNRIs).\u201d <em>Healthline<\/em>. <a href=\"https:\/\/www.healthline.com\/health\/depression\/serotonin-norepinephrine-reuptake-inhibitors-snris\" target=\"_blank\" rel=\"noopener\">https:\/\/www.healthline.com\/health\/depression\/serotonin-norepinephrine-reuptake-inhibitors-snris<\/a><\/p>\n\n\n\n<p>Mayo Clinic Staff. \u201cAnxiety Disorders.\u201d <em>Mayo Clinic<\/em>. <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/anxiety\/symptoms-causes\/syc-20350961\" target=\"_blank\" rel=\"noopener\">https:\/\/www.mayoclinic.org\/diseases-conditions\/anxiety\/symptoms-causes\/syc-20350961<\/a><\/p>\n\n\n\n<p>Mayo Clinic Staff. \u201cDepression (major depressive disorder).\u201d <em>Mayo Clinic<\/em>. <a href=\"https:\/\/www.webmd.com\/depression\/guide\/detecting-depression\" target=\"_blank\" rel=\"noopener\">https:\/\/www.webmd.com\/depression\/guide\/detecting-depression<\/a><\/p>\n\n\n\n<p>\u201cSide effects &#8211; Selective serotonin reuptake inhibitors (SSRIs).\u201d <em>NHS<\/em>. <a href=\"https:\/\/www.nhs.uk\/mental-health\/talking-therapies-medicine-treatments\/medicines-and-psychiatry\/ssri-antidepressants\/side-effects\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.nhs.uk\/mental-health\/talking-therapies-medicine-treatments\/medicines-and-psychiatry\/ssri-antidepressants\/side-effects\/<\/a><\/p>\n\n\n\n<p>\u201cSerotonin.\u201d<em> Cleaveland Clinic<\/em>. <a href=\"https:\/\/my.clevelandclinic.org\/health\/articles\/22572-serotonin\" target=\"_blank\" rel=\"noopener\">https:\/\/my.clevelandclinic.org\/health\/articles\/22572-serotonin<\/a><\/p>\n\n\n\n<p>Zawn Villines. \u201cWhat are the differences between SSRIs and SNRIs?\u201d <em>Medical News Today<\/em>. <a href=\"https:\/\/www.medicalnewstoday.com\/articles\/ssri-vs-snri\" target=\"_blank\" rel=\"noopener\">https:\/\/www.medicalnewstoday.com\/articles\/ssri-vs-snri<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>If you suffer from anxiety or depression, you\u2019ve probably heard about SSRIs and SNRIs.&nbsp; Though both drug types are clinically effective at treating depression and anxiety, there are differences that might make one option more suitable for treating your particular symptoms.&nbsp; In this article, we\u2019ll discuss both types of antidepressants so you can better understand [&hellip;]<\/p>\n","protected":false},"author":29,"featured_media":5574,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17,18],"tags":[74,75],"temp_settings":[116],"_links":{"self":[{"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/posts\/5573"}],"collection":[{"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/comments?post=5573"}],"version-history":[{"count":12,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/posts\/5573\/revisions"}],"predecessor-version":[{"id":17200,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/posts\/5573\/revisions\/17200"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/media\/5574"}],"wp:attachment":[{"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/media?parent=5573"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/categories?post=5573"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/tags?post=5573"},{"taxonomy":"temp_settings","embeddable":true,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/temp_settings?post=5573"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}