{"id":4089,"date":"2022-10-04T07:04:00","date_gmt":"2022-10-04T14:04:00","guid":{"rendered":"https:\/\/cms.helloklarity.com\/?p=4089"},"modified":"2024-01-29T09:25:28","modified_gmt":"2024-01-29T17:25:28","slug":"ssris-vs-tricyclics","status":"publish","type":"post","link":"https:\/\/cms.helloklarity.com\/post\/ssris-vs-tricyclics\/","title":{"rendered":"SSRIs vs. Tricyclics: Which One Should I Take?"},"content":{"rendered":"\n<p>Are you experiencing symptoms of anxiety or depression and are unsure which treatment option is best for you? With so many different medications available, it may seem difficult to understand which medication to choose.&nbsp;<\/p>\n\n\n\n<p>In this article, we\u2019ll discuss the difference between SSRIs and tricyclics, two common classes of drugs used to treat anxiety and depression. While both types of medications are proven to be effective, there are differences in their side effects, cost, and warnings associated with each medication. It is important to understand the key differences between prescription medications in order to have an informed discussion with your healthcare provider about which treatment option is right for you.&nbsp;<\/p>\n\n\n\n<p>When researching medications like SSRIs or tricyclics online, you should never attempt to self-diagnose or self-medicate. Always consult with a healthcare professional to find the safest and most effective treatment based on your symptoms, medical history, and more.&nbsp;<\/p>\n\n\n\n<p>If you need a reliable and affordable way to access treatment for your anxiety or depression,&nbsp; Klarity can help. We\u2019ll match you with a licensed healthcare provider in your state for convenient, insurance-free online mental health treatment. Your provider will evaluate your symptoms and help you decide if an SSRI or tricyclic is right for you. <a href=\"https:\/\/care.klarityadhd.com\/assessment\/get-started\" target=\"_blank\" rel=\"noopener\">Schedule an appointment<\/a> today.<\/p>\n\n\n\n<p><em>This article discusses suicide, suicidal ideation, and self-harm. If you or someone you know is experiencing suicidal thoughts or is in crisis, contact the Suicide Prevention Lifeline immediately at 800-273-8255.<\/em><\/p>\n\n\n\n<table id=\"tablepress-20\" class=\"tablepress tablepress-id-20 tablepress-responsive\">\n<thead>\n<tr class=\"row-1 odd\">\n\t<th class=\"column-1\"><\/th><th class=\"column-2\">SSRIs<\/th><th class=\"column-3\">Tricyclics<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-hover\">\n<tr class=\"row-2 even\">\n\t<td class=\"column-1\"><strong>Drug Class<\/strong><\/td><td class=\"column-2\">Selective serotonin reuptake inhibitors (SSRIs)<\/td><td class=\"column-3\">Tricyclic antidepressants (TCAs)<\/td>\n<\/tr>\n<tr class=\"row-3 odd\">\n\t<td class=\"column-1\"><strong>Brand \/ Generic Status<\/strong><\/td><td class=\"column-2\">Brand-names and generics available<br \/>\n<br \/>\nMost common SSRIs:  <br \/>\n\u2022 Prozac (fluoxetine)<br \/>\n\u2022 Paxil (paroxetine)<br \/>\n\u2022 Zoloft (sertraline)<br \/>\n\u2022 Celexa (citalopram)<br \/>\n\u2022 Luvox (fluvoxamine)<br \/>\n\u2022 Lexapro (escitalopram)<br \/>\n\u2022 Trintellix (vortioxetine)<br \/>\n\u2022 Viibryd (vilazodone)<br \/>\n<\/td><td class=\"column-3\">Brand-names and generics available<br \/>\n<br \/>\nMost common TCAs: <br \/>\n\u2022 Tofranil (imipramine hydrochloride)<br \/>\n\u2022 Pamelor (nortriptyline)<br \/>\n\u2022 Asendin (amoxapine)<br \/>\n\u2022 Elavil (amitriptyline)<br \/>\n\u2022 Surmontil (trimipramine)  <br \/>\n\u2022 Vivactil (protriptyline) <br \/>\n\u2022 Silenor (doxepin) <br \/>\n\u2022 Zonalong or Prudoxin (doxepin)<br \/>\n\u2022 Norpramin (desipramine)<br \/>\n<br \/>\n<\/td>\n<\/tr>\n<tr class=\"row-4 even\">\n\t<td class=\"column-1\"><strong>Form(s) of the Drug<\/strong><\/td><td class=\"column-2\">Common forms of SSRIs include:<br \/>\n\u2022 Color-coded* capsules<br \/>\n\u2022 Color-coded* tablets<br \/>\n\u2022 Flavored liquid suspensions<br \/>\n<br \/>\n*Color-coding often indicates dosage amount<\/td><td class=\"column-3\">Common forms of TCAs include: <br \/>\n\u2022 Capsules<br \/>\n\u2022 Tablets<br \/>\n\u2022 Flavored liquid suspensions<br \/>\n<br \/>\n<\/td>\n<\/tr>\n<tr class=\"row-5 odd\">\n\t<td class=\"column-1\"><strong>Standard Dosage<\/strong><\/td><td class=\"column-2\">Varies, depending on SSRI and condition being treated<br \/>\n<br \/>\n<\/td><td class=\"column-3\">Varies, depending on TCA and condition being treated<\/td>\n<\/tr>\n<tr class=\"row-6 even\">\n\t<td class=\"column-1\"><strong>Conditions Treated<\/strong><\/td><td class=\"column-2\">Conditions most often treated: <br \/>\n\u2022 Major depressive disorder<br \/>\n\u2022 Generalized anxiety disorder<br \/>\n<br \/>\nOther conditions treated: <br \/>\n\u2022 Obsessive-compulsive disorder (OCD)<br \/>\n\u2022 Eating disorders<br \/>\n\u2022 Premenstrual dysphoric disorder (PMDD)<br \/>\n<br \/>\nDifferent SSRIs are FDA-approved for different uses<br \/>\n<br \/>\nMany SSRIs are prescribed off-label to treat certain conditions<br \/>\n<\/td><td class=\"column-3\">Conditions most often treated: <br \/>\n\u2022 Depression<br \/>\n\u2022 Migraine headaches<br \/>\n<br \/>\nOther conditions treated: <br \/>\n\u2022 Obsessive-compulsive disorder (OCD)<br \/>\n\u2022 Anxiety disorders<br \/>\n\u2022 Insomnia<br \/>\n\u2022 Chronic pain<br \/>\n\u2022 Neuropathic pain<br \/>\n\u2022 Nerve pain<br \/>\n\u2022 Itching and eczema<br \/>\n<br \/>\nDifferent TCAs are FDA-approved for different uses<br \/>\n<br \/>\nMany TCAs are prescribed off-label to treat certain conditions<br \/>\n<\/td>\n<\/tr>\n<tr class=\"row-7 odd\">\n\t<td class=\"column-1\"><strong>Cost<\/strong><\/td><td class=\"column-2\">Average cost of a 30-day supply:<br \/>\n\u2022 $4 to $40 for generic formulas*<br \/>\n\u2022 $130 or more for brand-name formulas**<br \/>\n<br \/>\n*Some SSRIs don\u2019t have a generic formula available for Rx.<br \/>\n<br \/>\n**Cost of brand-name SSRIs may be offset by coupons and insurance<br \/>\n<\/td><td class=\"column-3\">Average cost of a 30-day supply: <br \/>\n\u2022 $20 for a 30-day supply of: <br \/>\n       \u2022 Amitriptyline <br \/>\n       \u2022 Pamelor<br \/>\n       \u2022 Silenor<br \/>\n       \u2022 Norpramin<br \/>\n       \u2022 Tofranil<br \/>\n\u2022 $120 or more for most other tricyclics*<br \/>\n<br \/>\n*Most TCAs are covered under insurance<\/td>\n<\/tr>\n<tr class=\"row-8 even\">\n\t<td class=\"column-1\"><strong>Side-Effects<\/strong><\/td><td class=\"column-2\">Common side effects:<br \/>\n\u2022 Nausea, vomiting, GI upset, or diarrhea<br \/>\n\u2022 Dry mouth <br \/>\n\u2022 Headache <br \/>\n\u2022 Difficulty sleeping or insomnia <br \/>\n\u2022 Drowsiness or dizziness <br \/>\n\u2022 Increased nervousness, feelings of restlessness, or agitation<br \/>\n\u2022 Reduced libido, erectile dysfunction <br \/>\n\u2022 Increase or decrease appetite, leading to changes in weight<br \/>\n<\/td><td class=\"column-3\">Common side effects: <br \/>\n\u2022 Drowsiness<br \/>\n\u2022 Constipation<br \/>\n\u2022 Dry mouth<br \/>\n\u2022 Blurred vision <br \/>\n\u2022 Orthostatic hypotension<br \/>\n\u2022 Urine retention <br \/>\n\u2022 Increased sweating <br \/>\n\u2022 Tremors <br \/>\n\u2022 Increased or decreased appetite  <br \/>\n\u2022 Sexual dysfunction<br \/>\n<\/td>\n<\/tr>\n<tr class=\"row-9 odd\">\n\t<td class=\"column-1\"><strong>Warnings For Use<\/strong><\/td><td class=\"column-2\">\u2022 Combination with other medications may cause serotonin syndrome<br \/>\n\u2022 Symptoms of serotonin syndrome include: <br \/>\n      \u2022 Anxiety or agitation<br \/>\n      \u2022 Fever, sweating<br \/>\n      \u2022 Tremors<br \/>\n      \u2022 Restlessness<br \/>\n      \u2022 Confusion<br \/>\n      \u2022 Lack of coordination<br \/>\n      \u2022 Blood pressure and heart rate changes<br \/>\n<br \/>\n\u2022 Rarely, SSRIs may cause <br \/>\nsuicidal thoughts or behaviors<br \/>\n      \u2022 Contact your doctor immediately if this occurs<br \/>\n<\/td><td class=\"column-3\">\u2022 Combination with other medications may cause serotonin syndrome<br \/>\n\u2022 Symptoms of serotonin syndrome include: <br \/>\n      \u2022 Anxiety or agitation<br \/>\n      \u2022 Fever, sweating<br \/>\n      \u2022 Tremors<br \/>\n      \u2022 Restlessness<br \/>\n      \u2022 Confusion<br \/>\n      \u2022 Lack of coordination<br \/>\n      \u2022 Blood pressure and heart rate changes<br \/>\n\u2022 May cause seizures or falls in those prone to them<br \/>\n\u2022 Do not mix with alcohol<br \/>\n\u2022 Rarely, TCAs cause suicidal thoughts or behaviors<br \/>\n      \u2022 Contact your doctor immediately if this occurs<br \/>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-20 from cache -->\n\n\n\n<h2 class=\"wp-block-heading\">SSRIs<\/h2>\n\n\n\n<p>Selective Serotonin Reuptake Inhibitors (SSRIs) are the most commonly prescribed medications used to treat anxiety and depression. SSRIs are used in both adolescent and adult populations and have been found to be one of the most effective types of drugs for improving mood and reducing anxiety.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">How Do SSRIs Work?<\/h3>\n\n\n\n<p>Serotonin is a chemical neurotransmitter that is naturally found in the brain. It acts as a messenger between the nerve cells and plays an important role in many bodily functions, such as mood, sleep, and digestion.&nbsp;<\/p>\n\n\n\n<p>Research has shown that serotonin levels are reduced in patients that suffer from depression and anxiety. SSRIs work by increasing the amount of available serotonin in the brain by blocking the reabsorption or reuptake of serotonin into neurons.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What Do SSRIs Treat?<\/h3>\n\n\n\n<p>SSRIs are the most commonly prescribed medications for anxiety and depression. They have been found to be the most effective class of medications to improve mood and are safely used in both children and adults.&nbsp;<\/p>\n\n\n\n<p>Anxiety and depression are often diagnosed concurrently in patients, making this class of medications useful when treating those who are suffering from both. In addition, SSRIs are also used to treat eating disorders, obsessive-compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder (PMDD).&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Depression<\/h4>\n\n\n\n<p>Depression is a serious mood disorder that affects a patient\u2019s everyday life. This condition impacts the patient&#8217;s feelings, alters the thinking process, and disrupts their daily activities. There are many different types of depression, with the most common being known as major depressive disorder.&nbsp;<\/p>\n\n\n\n<p>Chronic depression, also known as major depressive disorder (MDD), consists of various symptoms of depression that occur for the majority of at least two weeks and interfere with everyday life. Some common symptoms include:&nbsp;<\/p>\n\n\n\n<ul>\n<li>Persistent depressed mood<\/li>\n\n\n\n<li>Feelings of hopelessness, helplessness, irritability, or restlessness<\/li>\n\n\n\n<li>Loss of interest in pleasurable activities<\/li>\n\n\n\n<li>Difficulty concentrating<\/li>\n\n\n\n<li>Sleep disruption<\/li>\n\n\n\n<li>Changes in appetite&nbsp;<\/li>\n\n\n\n<li>Physical symptoms, such as headaches, fatigue, and various pain throughout the body.&nbsp;<\/li>\n\n\n\n<li>Increased thoughts of death, suicide, or self-harm.&nbsp;<\/li>\n<\/ul>\n\n\n\n<p>People with depression tend to have lower levels of serotonin, and SSRIs work by increasing the levels of serotonin in the brain. SSRIs have been shown to be highly effective in improving mood and are one of the most common forms of depression treatment today.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Anxiety<\/h4>\n\n\n\n<p>Anxiety is a normal physiological reaction to any perceived stressor in life. However, patients who suffer from anxiety disorders experience intense, constant, or excessive fear and worry about everyday life events and situations. Similar to depression, there are a number of different types of anxiety disorders, with the most common being Generalized Anxiety Disorder (GAD).&nbsp;<\/p>\n\n\n\n<p>GAD consists of increased anxiety or worry surrounding everyday life events or situations. The level of worry is considered to be exaggerated or out of proportion with the given circumstances and is often challenging to control. In addition, a patient with anxiety often experiences physical symptoms, such as an increased heart rate, irregular heartbeats, chest pain, or shortness of breath.&nbsp;&nbsp;<\/p>\n\n\n\n<p>Other common anxiety disorders that are effectively treated with SSRIs include obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and panic disorder. They are also frequently prescribed to treat OCD-related phobias, such as agoraphobia and social phobia.&nbsp;<\/p>\n\n\n\n<p>By increasing the levels of serotonin in the brain, SSRIs work to calm overwhelming thoughts or feelings of worry. This class of medication has been proven to be one of the most effective forms of treatment for various anxiety disorders.&nbsp;<\/p>\n\n\n\t\t<div data-elementor-type=\"page\" data-elementor-id=\"15401\" class=\"elementor elementor-15401\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c521b1f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c521b1f\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1e5f769\" data-id=\"1e5f769\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-8537e6b elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8537e6b\" data-element_type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-f020c0d\" data-id=\"f020c0d\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2478e2a elementor-widget__width-auto elementor-widget elementor-widget-heading\" data-id=\"2478e2a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.19.0 - 07-02-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-large\">Licensed providers on Klarity provide personalized treatment. \nFind a provider that matches your needs and preferences.<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-87df69e elementor-widget elementor-widget-spacer\" data-id=\"87df69e\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.19.0 - 07-02-2024 *\/\n.elementor-column .elementor-spacer-inner{height:var(--spacer-size)}.e-con{--container-widget-width:100%}.e-con-inner>.elementor-widget-spacer,.e-con>.elementor-widget-spacer{width:var(--container-widget-width,var(--spacer-size));--align-self:var(--container-widget-align-self,initial);--flex-shrink:0}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container,.e-con>.elementor-widget-spacer>.elementor-widget-container{height:100%;width:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer{height:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner{height:var(--container-widget-height,var(--spacer-size))}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty,.e-con>.elementor-widget-spacer.elementor-widget-empty{position:relative;min-height:22px;min-width:22px}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon,.e-con>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon{position:absolute;top:0;bottom:0;left:0;right:0;margin:auto;padding:0;width:22px;height:22px}<\/style>\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-76f1234 elementor-widget-tablet__width-inherit elementor-tablet-align-center elementor-align-center elementor-widget__width-auto elementor-widget elementor-widget-button\" data-id=\"76f1234\" data-element_type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_on&quot;:[&quot;mobile&quot;],&quot;sticky_offset_mobile&quot;:0,&quot;sticky_effects_offset_mobile&quot;:0,&quot;sticky_offset&quot;:0,&quot;sticky_effects_offset&quot;:0}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/care.helloklarity.com\/assessment\/get-started?utm_source=blog&#038;utm_medium=cta&#038;utm_campaign=blue\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Find a provider<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t\n\n\n\n<h3 class=\"wp-block-heading\">What Are the Most Commonly Prescribed SSRIs?<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\">Prozac<\/h4>\n\n\n\n<p>Prozac (fluoxetine) is most commonly prescribed for mood disorders, such as depression, OCD, and panic disorder. It is also commonly prescribed to treat eating disorders like bulimia.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Paxil<\/h4>\n\n\n\n<p>Paxil (paroxetine) is primarily prescribed for depression but may also be used to treat generalized anxiety disorders, OCD, panic attacks, PTSD, and PMDD.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Zoloft<\/h4>\n\n\n\n<p>Zoloft (sertraline) is used to treat depression, OCD, panic disorders, PTSD, PMDD, and social anxiety. This is one of the more popular medications prescribed compared to other drugs in this class.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Celexa<\/h4>\n\n\n\n<p><a href=\"https:\/\/www.klarityadhd.com\/post\/prozac-vs-celexa\/\" data-type=\"link\" data-id=\"https:\/\/www.klarityadhd.com\/post\/prozac-vs-celexa\/\" target=\"_blank\" rel=\"noopener\">Celexa<\/a> (citalopram) is typically used to treat depression, but tends to be slightly less popular than other SSRIs. This is likely because this Celexa has been shown to be less effective than other SSRI options in research studies.\u00a0<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Luvox<\/h4>\n\n\n\n<p>Luvox (fluvoxamine) is an SSRI used to treat OCD. While it is not FDA-approved to treat generalized anxiety or depression, it is sometimes prescribed off-label for patients with severe depression.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Lexapro<\/h4>\n\n\n\n<p>Lexapro (escitalopram) is a common medication to treat depression and most types of anxiety disorders. This drug is fairly popular and commonly prescribed.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Trintellix<\/h4>\n\n\n\n<p>Trintellix (vortioxetine) is a serotonin modulator and is pharmacologically unique compared to other SSRIs. This is commonly used to treat major depressive disorder. There is no generic alternative available, making this medication more expensive compared to other SSRIs.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Viibryd<\/h4>\n\n\n\n<p>Viibryd (vilazodone) is a newer SSRI used to treat depression. This medication tends to be less popular than other SSRIs and does not have a generic alternative.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Costs<\/h3>\n\n\n\n<p>The cost of SSRIs varies drastically depending on the specific medication, as well as generic versus name-brand formulations. Overall, this class of medication is fairly inexpensive, and the majority of SSRIs come available in both generic and name-brand versions. Some of the most affordable SSRIs include Zoloft, Prozac, Lexapro, Celexa, and Paxil.&nbsp;<\/p>\n\n\n\n<p>The average cost of a 30-day supply of SSRIs ranges from $4 &#8211; $40 for generic name medications when using a coupon card at the pharmacy. Some SSRIs do not have a generic formulation and are more expensive, such as Luvox, with a higher cost for a 30-day supply at around $130. The majority of these medications are covered by insurance, and prescription coupon cards are available at most pharmacies.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Common Side Effects<\/h3>\n\n\n\n<p>The most common side effects of SSRIs include:&nbsp;<\/p>\n\n\n\n<ul>\n<li>Nausea, vomiting, GI upset, or diarrhea<\/li>\n\n\n\n<li>Dry mouth&nbsp;<\/li>\n\n\n\n<li>Headache&nbsp;<\/li>\n\n\n\n<li>Difficulty sleeping or insomnia&nbsp;<\/li>\n\n\n\n<li>Drowsiness or dizziness&nbsp;<\/li>\n\n\n\n<li>Increased nervousness, feelings of restlessness, or agitation<\/li>\n\n\n\n<li>Reduced libido, erectile dysfunction&nbsp;<\/li>\n\n\n\n<li>Weight changes related to increased or decreased appetite<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Warnings for Use<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\">Serotonin Syndrome<\/h4>\n\n\n\n<p>Serotonin Syndrome is a rare but serious condition that occurs when high serotonin levels accumulate in the body. Signs and symptoms include:<\/p>\n\n\n\n<ul>\n<li>Anxiety or agitation<\/li>\n\n\n\n<li>Fever<\/li>\n\n\n\n<li>Increased sweating<\/li>\n\n\n\n<li>Tremors<\/li>\n\n\n\n<li>Feelings of restlessness<\/li>\n\n\n\n<li>Lack of coordination or confusion<\/li>\n\n\n\n<li>Changes in the patient&#8217;s blood pressure and heart rate<\/li>\n<\/ul>\n\n\n\n<p>This is commonly seen in patients who are taking multiple medications that increase serotonin levels in the body simultaneously. It is important to immediately seek medical attention if you begin to experience these symptoms and inform your healthcare provider of all the medications you are taking before being started on an antidepressant.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Suicidal Thoughts or Behaviors<\/h4>\n\n\n\n<p>An increase in suicidal thoughts or behaviors has been seen in some patients that are started on SSRIs. This is rare, but is most frequently seen in adolescents and young adults under the age of 25. Contact your healthcare provider immediately if you begin to experience suicidal thoughts, ideations, or behaviors like self-harm.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Withdrawal<\/h4>\n\n\n\n<p>Abrupt discontinuation of an SSRI may result in withdrawal-like symptoms. If you are unhappy with your prescription, you should work with your healthcare provider to gradually taper off the medication or modify your dosage. Common withdrawal symptoms include:&nbsp;<\/p>\n\n\n\n<ul>\n<li>Flu-like symptoms: muscle aches or pain, chills, fatigue&nbsp;<\/li>\n\n\n\n<li>Sleep disturbances, such as insomnia or nightmares&nbsp;<\/li>\n\n\n\n<li>Nausea, vomiting, abdominal discomfort<\/li>\n\n\n\n<li>Imbalance or lack of coordination&nbsp;<\/li>\n\n\n\n<li>Sensory disturbances, such as tremors or sensations of electric shock<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Tricyclics<\/h2>\n\n\n\n<p>Tricyclic antidepressants, or TCAs, are another common treatment used for depression and anxiety. This class of medications is among some of the oldest forms of antidepressant medications developed, but due to their side effect profile, they have become less popular in treating the general population. However, this type of medication remains to be a good option for some.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">How Do Tricyclics Work?<\/h3>\n\n\n\n<p>TCAs work by acting on a number of different chemical neurotransmitter pathways or messaging systems in the brain. Similar to SSRIs, tricyclics block the reuptake of serotonin. In addition, these antidepressants block the reuptake of another neurotransmitter, norepinephrine, leading to increased levels of both in the brain.&nbsp;<\/p>\n\n\n\n<p>Tricyclic antidepressants have been phased out as a popular treatment because they also target other chemicals in the brain unrelated to mood, which can lead to an increased risk of side effects. However, patients who find SSRIs ineffective may benefit from tricyclics.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What Do Tricyclics Treat?<\/h3>\n\n\n\n<p>Tricyclics are primarily used to treat depression and prevent migraines. In some circumstances, they are used to treat OCD, anxiety disorders, insomnia, as well as chronic neuropathic pain due to dysfunction of the nerves. Tricyclic antidepressants may also be used to treat migraine headaches, bed-wetting, insomnia, itching, and eczema.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Depression<\/h4>\n\n\n\n<p>Tricyclic antidepressants remain to be one of the earliest pharmacologically developed medications used to treat depression. There are a number of different depressive disorders, with the most common being major depressive disorder (MDD). MDD consists of various symptoms of depression that occur for the majority of at least two weeks and interfere with everyday life.&nbsp;<\/p>\n\n\n\n<p>Some common symptoms of MDD include:<\/p>\n\n\n\n<ul>\n<li>Persistent depressed mood<\/li>\n\n\n\n<li>Los of interest in pleasurable activities&nbsp;<\/li>\n\n\n\n<li>Feelings of hopelessness or helplessness<\/li>\n\n\n\n<li>Irritability or restlessness<\/li>\n\n\n\n<li>Difficulty concentrating&nbsp;<\/li>\n\n\n\n<li>Sleep disruption, including insomnia or increased need for sleep<\/li>\n\n\n\n<li>Changes in appetite, leading to weight loss or gain<\/li>\n\n\n\n<li>Physical symptoms: headaches, fatigue, pain in various areas<\/li>\n\n\n\n<li>Severe can increase thoughts of death, suicide, or self-harm<\/li>\n<\/ul>\n\n\n\n<p>Those who suffer from severe depression tend to have lower levels of serotonin and norepinephrine in the brain. Tricyclic antidepressants work by increasing these two neurochemical messengers to improve depressive symptoms.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Anxiety<\/h4>\n\n\n\n<p>Anxiety is known to be an exaggerated biological response to a perceived threat or life stressor. Anxiety disorders include generalized anxiety disorder (GAD), obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and panic disorder. Of these, GAD is the most commonly diagnosed.&nbsp;<\/p>\n\n\n\n<p>TCAs were one of the first medications to be developed for the treatment of anxiety and are still used today. By acting on two different neurotransmitters in the brain, they have been shown to be effective in easing feelings of worry and controlling racing thoughts in those who suffer from anxiety.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What Are the Most Commonly Prescribed Tricyclics?<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\">Tofranil<\/h4>\n\n\n\n<p>Tofranil (imipramine hydrochloride) is commonly prescribed to treat depression, as well as nighttime bed wetting in children.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Pamelor<\/h4>\n\n\n\n<p>Pamelor (nortriptyline) is used to treat depression. It remains to be slightly less popular compared to other tricyclic medications, due to an increase in negative interactions with other common medications. It is also slightly more expensive than other TCAs.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Asendin<\/h4>\n\n\n\n<p>Asendin (amoxapine) is used to treat depression and anxiety disorders. This drug typically needs to be taken right before bedtime due to drowsiness.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Elavil<\/h4>\n\n\n\n<p>Elavil (amitriptyline) is a commonly prescribed drug used to treat migraine headaches and major depressive disorder. It is one of the most commonly prescribed tricyclic medications. Amitriptyline is only available as a generic drug, and in addition to Elavil, other generic names include Amitid, Amitril, and Endep.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Surmontil<\/h4>\n\n\n\n<p>Surmontil (trimipramine) is another TCA used to treat depression. This medication is available as a capsule and is taken one to three times a day.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Vivactil&nbsp;&nbsp;<\/h4>\n\n\n\n<p>Vivactil (protriptyline) is prescribed to treat depression. This medication is less popular because it is more expensive than other tricyclics, and patients typically need to take multiple doses per day.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Doxepin<\/h4>\n\n\n\n<p>Silenor (doxepin) is primarily used to treat insomnia and helps you sleep throughout the night. There are currently no available generic alternatives for this medication, and it remains to be less popular than other comparable medications.&nbsp;<\/p>\n\n\n\n<p>Zonalong or Prudoxin (doxepin) is another form of this tricyclic medication and is prescribed to reduce itching that is caused by various skin conditions, such as eczema.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Norpramin<\/h4>\n\n\n\n<p>Norpramin (desipramine) is used to treat depression. It is not as commonly prescribed compared to other tricyclics.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Costs<\/h3>\n\n\n\n<p>The cost of tricyclic antidepressants varies based on the specific drug prescribed. Overall, tricyclics are more expensive than SSRIs. The least expensive tricyclics include Amitriptyline, Pamelor, Silenor, Norpramin, and Tofranil. A 30-day supply of these medications is under $20 with a coupon card that is available at most pharmacies.&nbsp;<\/p>\n\n\n\n<p>Other tricyclics are more expensive, and a 30-day supply can reach over $120 with a coupon card. The majority of these medications are covered by insurance.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Common Side Effects<\/h3>\n\n\n\n<p>Due to the side effect profile of this class of medications, other drugs have become more popular in the treatment of depression.&nbsp;<\/p>\n\n\n\n<p>Some of the most common side effects include:&nbsp;<\/p>\n\n\n\n<ul>\n<li>Drowsiness<\/li>\n\n\n\n<li>Constipation<\/li>\n\n\n\n<li>Dry mouth<\/li>\n\n\n\n<li>Blurred vision&nbsp;<\/li>\n\n\n\n<li>Orthostatic hypotension, or a drop in blood pressure when the patient moves from a sitting to a standing position, causing lightheadedness while standing up&nbsp;<\/li>\n\n\n\n<li>Urine retention&nbsp;<\/li>\n\n\n\n<li>Increased sweating&nbsp;<\/li>\n\n\n\n<li>Tremors&nbsp;<\/li>\n\n\n\n<li>Increased or decreased appetite, leading to changes in weight&nbsp;&nbsp;<\/li>\n\n\n\n<li>Sexual dysfunction, including decreased libido or inability to maintain an erection&nbsp;<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Warnings for Use<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\">Falls<\/h4>\n\n\n\n<p>Due to the physical side effects associated with tricyclics, safety is a major concern when starting one of these medications, especially in the elderly or when on a high dose. Falls are a common safety concern due to disorientation or confusion.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Contraindications with other Diseases or Drugs<\/h4>\n\n\n\n<p>All past and current health conditions should be disclosed and discussed with your healthcare provider before starting a tricyclic antidepressant. Of note, certain comorbid conditions may impact the safety of using a tricyclic medication, including glaucoma, heart issues, diabetes, enlarged prostate, liver disease, or a seizure disorder.&nbsp;<\/p>\n\n\n\n<p>Tricyclics may also cause elevated or irregular heartbeat, as well as an increased risk of seizure in those who are prone to seizures. <strong>Do not drink alcohol while taking a tricyclic antidepressant, as this can worsen the side effects of the medication.&nbsp;<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Overdose &amp; Suicide<\/h4>\n\n\n\n<p>Overdose with tricyclic antidepressants can be dangerous and even lethal in some cases. All medications, including over-the-counter medications and supplements, should be reviewed with your physician before starting an antidepressant.&nbsp;<\/p>\n\n\n\n<p>Tricyclics should be avoided in patients with a history of suicidal thoughts or attempts. As with SSRIs, there is also a rare but serious concern for increased suicidal thoughts or behaviors, and should be closely monitored in adolescents and young adults under the age of 25.&nbsp;<\/p>\n\n\n\n<p><strong>If you are experiencing thoughts of self-harm or suicide, contact your healthcare provider immediately or go to the emergency department. The suicide hotline number is 988, and this service is available 24\/7.&nbsp;<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Serotonin Syndrome<\/h4>\n\n\n\n<p>Serotonin syndrome is a rare but serious condition that occurs when serotonin levels accumulate in the body. Signs and symptoms include anxiety or agitation, fever, increased sweating, tremors, feelings of restlessness, lack of coordination or confusion, and changes in the patient&#8217;s blood pressure and heart rate.&nbsp;<\/p>\n\n\n\n<p>This is commonly seen in patients who are taking multiple medications that increase serotonin levels in the body simultaneously. It is important to immediately seek medical attention if you begin to experience these symptoms and inform your physician of all the medications you are taking before being started on an antidepressant.&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Discontinuation Syndrome<\/h4>\n\n\n\n<p>Abrupt discontinuation or missing several doses of a tricyclic antidepressant may result in withdrawal-like symptoms. If you are no longer happy with your tricyclic antidepressant, you should work with your physician to gradually and safely stop the medication. Common discontinuation syndrome symptoms include:&nbsp;<\/p>\n\n\n\n<ul>\n<li>Increased agitation, irritability, or anxiety&nbsp;<\/li>\n\n\n\n<li>Flu-like symptoms, such as muscle aches or pains, chills, fatigue&nbsp;<\/li>\n\n\n\n<li>Insomnia&nbsp;<\/li>\n\n\n\n<li>Nausea, vomiting, abdominal discomfort<\/li>\n\n\n\n<li>Increased sweating<\/li>\n\n\n\n<li>Headache&nbsp;<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">SSRIs or Tricyclics: Which is Right For You?<\/h2>\n\n\n\n<p>With so many different treatment options available for anxiety and depression, it can be overwhelming to decide which medication is the right one for you. Everyone reacts differently to antidepressants, and the dose or type of medication may also need to be adjusted throughout your treatment process.<\/p>\n\n\n\n<p>While SSRIs are a more popular choice when treating depression, some patients may feel that tricyclics are more effective. However, others may feel that the complex side effects of tricyclics are too risky, and would prefer taking an SSRI as a safer form of treatment.&nbsp;<\/p>\n\n\n\n<p>For these reasons, you should never attempt to self-diagnose or self-medicate online, and should instead always consult with a medical professional before starting any antidepressant medications.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Get Depression Treatment Online With Help From Klarity<\/h2>\n\n\n\n<p>If you need a reliable and affordable way to access depression medication, Klarity can help. The healthcare providers on Klarity offer <a href=\"https:\/\/www.klarityadhd.com\/depression\/\" target=\"_blank\" rel=\"noopener\">quality depression treatment online<\/a>, including diagnosis and prescription medications such as SSRIs or tricyclics, if deemed necessary.&nbsp;<\/p>\n\n\n\n<p>Your healthcare provider will help navigate this process with you to find the best individualized treatment plan for your depression. <a href=\"https:\/\/care.klarityadhd.com\/assessment\/get-started\" target=\"_blank\" rel=\"noopener\">Schedule your first telehealth appointment<\/a> on Klarity today, and in just 48 hours you could receive a prescription to help you finally take control of your depression.&nbsp;<\/p>\n\n\n\n<p>Resources:&nbsp;<\/p>\n\n\n\n<ul>\n<li><a href=\"https:\/\/www.goodrx.com\/classes\/ssris\" target=\"_blank\" rel=\"noopener\">https:\/\/www.goodrx.com\/classes\/ssris<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nimh.nih.gov\/health\/topics\/depression\" target=\"_blank\" rel=\"noopener\">https:\/\/www.nimh.nih.gov\/health\/topics\/depression<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/depression\/in-depth\/ssris\/art-20044825\" target=\"_blank\" rel=\"noopener\">https:\/\/www.mayoclinic.org\/diseases-conditions\/depression\/in-depth\/ssris\/art-20044825<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/depression\/in-depth\/antidepressants\/art-20046983\" target=\"_blank\" rel=\"noopener\">https:\/\/www.mayoclinic.org\/diseases-conditions\/depression\/in-depth\/antidepressants\/art-20046983<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.goodrx.com\/classes\/tricyclic-antidepressants\" target=\"_blank\" rel=\"noopener\">https:\/\/www.goodrx.com\/classes\/tricyclic-antidepressants<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Are you experiencing symptoms of anxiety or depression and are unsure which treatment option is best for you? With so many different medications available, it may seem difficult to understand which medication to choose.&nbsp; In this article, we\u2019ll discuss the difference between SSRIs and tricyclics, two common classes of drugs used to treat anxiety and [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":9001,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[75],"temp_settings":[],"_links":{"self":[{"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/posts\/4089"}],"collection":[{"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/comments?post=4089"}],"version-history":[{"count":13,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/posts\/4089\/revisions"}],"predecessor-version":[{"id":15927,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/posts\/4089\/revisions\/15927"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/media\/9001"}],"wp:attachment":[{"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/media?parent=4089"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/categories?post=4089"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/tags?post=4089"},{"taxonomy":"temp_settings","embeddable":true,"href":"https:\/\/cms.helloklarity.com\/wp-json\/wp\/v2\/temp_settings?post=4089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}