{"id":3454,"date":"2022-09-12T11:26:01","date_gmt":"2022-09-12T18:26:01","guid":{"rendered":"https:\/\/cms.helloklarity.com\/?p=3454"},"modified":"2024-02-14T05:52:44","modified_gmt":"2024-02-14T13:52:44","slug":"zoloft-vs-prozac","status":"publish","type":"post","link":"https:\/\/cms.helloklarity.com\/post\/zoloft-vs-prozac\/","title":{"rendered":"Zoloft vs. Prozac"},"content":{"rendered":"\n

Choosing to take medication to manage your anxiety can be difficult, especially when you\u2019re faced with a long list of available options. Even choosing between well-known medications like Zoloft and Prozac can be a significant challenge.  <\/p>\n\n\n\n

Both Prozac and Zoloft are selective serotonin reuptake inhibitors (SSRIs), which prevent neurons from reabsorbing serotonin, thereby increasing levels of available serotonin in the brain. These medications are commonly prescribed to treat anxiety and panic disorders due to their ability to regulate serotonin levels, promoting a sense of calm and reducing symptoms. However, Zoloft is more suitable for the treatment of social anxiety.<\/p>\n\n\n\n

Though Prozac and Zoloft are very similar, they have key differences, including medication interactions, that may make one a better choice than the other for each individual. In this article, we will compare Prozac and Zoloft so that you can have an informed discussion with your healthcare provider about which one could be right for you and your symptoms.<\/p>\n\n\n\n

If you suspect you have an anxiety disorder, find a provider<\/a> on Klarity today for affordable online anxiety treatment.<\/a> Your provider can diagnose your symptoms and create a personalized treatment plan for anxiety, including prescription SSRIs. With Klarity, you can receive comprehensive, insurance-free anxiety treatment in as little as 48 hours. <\/p>\n\n\n\n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t
<\/th>Zoloft<\/th>Prozac<\/th>\n<\/tr>\n<\/thead>\n
Drug Class<\/strong><\/td>Selective serotonin reuptake inhibitor (SSRI)<\/td>Selective serotonin reuptake inhibitor (SSRI)<\/td>\n<\/tr>\n
Brand \/ Generic Status<\/strong><\/td>Brand name for sertraline<\/td>Brand name fluoxetine<\/td>\n<\/tr>\n
Form(s) of the Drug<\/strong><\/td>\u2022 Clear, peppermint-flavored liquid suspension
\n\u2022 Color-coded tablets
\n<\/td>
\u2022 Clear, peppermint-flavored liquid suspension
\n\u2022 Half-green, half-white capsules
\n<\/td>\n<\/tr>\n
Standard Dosage<\/strong><\/td>Liquid suspension
\n\u2022 20 mg of sertraline per dose
\n
\nStandard tablet dosages:
\n\u2022 Green indicates 25 mg
\n\u2022 Blue indicates 50 mg
\n\u2022 Pinkish-red indicates 100 mg
\n<\/td>
Liquid suspension:
\n\u2022 10mg per dose
\n
\nCapsules:
\n\u2022 10mg per dose
\n<\/td>\n<\/tr>\n
Conditions Treated<\/strong><\/td>FDA-approved uses:
\n\u2022 Major depression
\n\u2022 Obsessive-compulsive disorder (OCD)
\n\u2022 Panic disorder
\n\u2022 Post-traumatic stress (PTS)
\n\u2022 Premenstrual dysphoric disorder (PMDD)
\n\u2022 Social anxiety disorder
\n
\nOff-label uses:
\n\u2022 Autism (mood stabilizing)
\n\u2022 Alcoholism
\n\u2022 Eating disorders
\n\u2022 Diabetic neuropathy
\n\u2022 Dementia
\n\u2022 Hot flashes
\n\u2022 Generalized anxiety disorder (GAD)
\n\u2022 Fibromyalgia
\n\u2022 Migraines
\n\u2022 Personality disorders
\n\u2022 Tourette syndrome
\n\u2022 Premature ejaculation<\/td>
FDA-approved uses:
\n\u2022 Anxiety and stress
\n\u2022 Major depression
\n\u2022 Bulimia nervosa
\n\u2022 Premenstrual dysphoric disorder (PMDD)
\n\u2022 Obsessive-compulsive disorder (OCD)
\n\u2022 Panic disorder
\n\u2022 Postpartum depression
\n\u2022 Schizoaffective disorder
\n
\nOff-label uses:
\n\u2022 Anorexia nervosa
\n\u2022 Premature ejaculation
\n\u2022 Various anxiety disorders
\n<\/td>\n<\/tr>\n
Cost<\/strong><\/td>Generic form (sertraline):
\n\u2022 $4 to $25 for 30 days\u2019 worth
\n
\nBrand-name:
\n\u2022 $215 to $315 for a 30-day supply
\n<\/td>
Generic form (fluoxetine):
\n\u2022 $3 to $4 for 30-days\u2019 worth of capsules*
\n\u2022 $12 for 30 days\u2019 worth of liquid suspension
\n
\n*May cost up to $100 for high dosages
\n
\nBrand-name:
\n\u2022 $460 to $1000 for 30 days\u2019 worth of capsules<\/td>\n<\/tr>\n
Side-Effects<\/strong><\/td>Common side effects:
\n\u2022 Nausea or indigestion
\n\u2022 Diarrhea or loose stool
\n\u2022 Tremors or twitching
\n\u2022 Decreased appetite and weight loss
\n\u2022 Bruising and muscle aches
\n\u2022 Decreased libido\/trouble orgasming
\n\u2022 Excessive sweating
\n\u2022 Anxiety
\n
\nSerious side effects:
\n\u2022 Heart arrhythmia
\n\u2022 Bleeding and liver injury
\n\u2022 Confusion and seizures
\n\u2022 Suicidal thoughts
\n\u2022 Changes in behavior
\n\u2022 Serotonin syndrome
\n<\/td>
Common side effects:
\n\u2022 Nausea
\n\u2022 Diarrhea or constipation
\n\u2022 Changes in appetite
\n\u2022 Headache and fatigue
\n\u2022 Increased sweating
\n\u2022 Trouble sleeping
\n\u2022 Impotence\/sexual dysfunction
\n
\nSerious side effects include:
\n\u2022 Fever
\n\u2022 High blood pressure
\n\u2022 Rigid muscles
\n\u2022 Seizures
\n\u2022 Kidney or respiratory failure
\n\u2022 Disorientation or delirium
\n\u2022 Serotonin syndrome
\n<\/td>\n<\/tr>\n
Warnings For Use<\/strong><\/td>Contraindicated conditions:
\n\u2022 Pregnancy or breastfeeding
\n\u2022 Liver problems
\n\u2022 Epilepsy and seizure disorders
\n\u2022 Glaucoma
\n\u2022 Bipolar disorder
\n\u2022 Thyroid disease
\n
\nDrug interactions:
\n\u2022 Monoamine oxidase inhibitors (MAOIs)
\n\u2022 Blood thinners
\n\u2022 Antipsychotic and antiseizure medications
\n\u2022 Alcohol\u2014recreational and alcohol-based medications
\n<\/td>
Contraindicated conditions:
\n\u2022 Diabetes
\n\u2022 Liver disease
\n\u2022 Alcohol use disorder
\n\u2022 History of bipolar disorder
\n\u2022 History of suicide attempts
\n\u2022 Low blood sodium or dehydration
\n\u2022 Seizures
\n\u2022 Gastrointestinal ulcers
\n\u2022 Glaucoma
\n
\nDrug Interactions:
\n\u2022 Monoamine oxidase inhibitors (MAOIs)
\n\u2022 Nonsteroidal anti-inflammatory drugs (NSAIDs)
\n\u2022 Aspirin and other blood thinners
\n\u2022 Antihistamines
\n\u2022 Opioid pain relievers
\n\u2022 St. John\u2019s wort
\n\u2022 Cannabis and MDMA
\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n

What Is Zoloft?<\/h2>\n\n\n\n

Zoloft is the brand name for the medication sertraline. It\u2019s an SSRI FDA-approved to treat depression in adults, and OCD in children and adolescents. Both the brand name and generic formula are available via prescription.  <\/p>\n\n\n\n

Zoloft is also prescribed off-label to treat a number of conditions that can result from a serotonin imbalance. This can be a preferable option for some, as It has less potential to cause drowsiness than other antidepressants. <\/p>\n\n\n\n

Zoloft Forms and Doses<\/h3>\n\n\n\n

Healthcare providers may prescribe Zoloft in two forms: tablets or liquid solution. The solution is typically given to children aged 6 to 12, while tablets are given to adolescents and adults aged 13 and older. <\/p>\n\n\n\n

Each dose of the liquid solution contains 20 mg of sertraline. It\u2019s a clear, peppermint-flavored suspension that must be properly diluted before it\u2019s administered. Each dose of the liquid solution contains 20 mg of sertraline. Dilution instructions come with each 60 ml bottle.<\/p>\n\n\n\n

Tablets are oblong, scored down the center, and stamped with the dosage amount. Dosages are also color-coded as follows: <\/p>\n\n\n\n

    \n
  • Green indicates 25 mg<\/li>\n\n\n\n
  • Blue indicates 50 mg<\/li>\n\n\n\n
  • Pinkish-red indicates 100 mg<\/li>\n<\/ul>\n\n\n\n

    Children 6 to 12 are usually prescribed a starting dose of 25 mg, while adults are prescribed 50 mg. Patients of all ages may increase their dosage 25 mg at a time, up to 200 mg, to maintain the effectiveness of the medication.<\/p>\n\n\n\n

    Conditions Zoloft Treats<\/h3>\n\n\n\n

    Zoloft can be prescribed in both on-label and off-label capacities. On-label indicates that it\u2019s been FDA-approved to treat those specific conditions. Off-label means that, while the drug may be effective in treating symptoms, it\u2019s not specifically approved by the FDA to do so. It\u2019s up to your healthcare provider to determine which medication will work best to treat your symptoms. <\/p>\n\n\n\n

    Zoloft is FDA-approved to treat the following conditions: <\/p>\n\n\n\n

      \n
    • Major depression<\/li>\n\n\n\n
    • Obsessive-compulsive disorder (OCD)<\/li>\n\n\n\n
    • Panic disorder<\/li>\n\n\n\n
    • Post-traumatic stress (PTS)<\/li>\n\n\n\n
    • Premenstrual dysphoric disorder (PMDD)<\/li>\n\n\n\n
    • Social anxiety disorder<\/li>\n<\/ul>\n\n\n\n

      Symptoms of Anxiety Zoloft Can Treat<\/h4>\n\n\n\n

      Zoloft is often prescribed off-label as an effective treatment for generalized anxiety disorder (GAD) and on-label for related conditions like social anxiety and panic disorder. <\/p>\n\n\n\n

      It\u2019s been shown to alleviate the following symptoms of these disorders: <\/p>\n\n\n\n

        \n
      • Unwanted or intrusive thoughts<\/li>\n\n\n\n
      • Intense fear<\/li>\n\n\n\n
      • Panic attacks <\/li>\n\n\n\n
      • Chronic feelings of anxiety<\/li>\n<\/ul>\n\n\n\n

        Symptoms of Depression Zoloft Can Treat<\/h4>\n\n\n\n

        When prescribed as an antidepressant, Zoloft can help improve many symptoms, including: <\/p>\n\n\n\n

          \n
        • Depressed, irritable, or fluctuating moods<\/li>\n\n\n\n
        • Disturbed sleep<\/li>\n\n\n\n
        • Irregular appetite cycles<\/li>\n\n\n\n
        • Low energy levels<\/li>\n\n\n\n
        • Disinterest in daily life<\/li>\n<\/ul>\n\n\n\n

          Off-Label Uses For Zoloft<\/h4>\n\n\n\n

          Zoloft is often prescribed off-label to treat the following conditions: <\/p>\n\n\n\n

            \n
          • Autism (mood stabilizing)<\/li>\n\n\n\n
          • Alcoholism<\/li>\n\n\n\n
          • Eating disorders<\/li>\n\n\n\n
          • Diabetic neuropathy<\/li>\n\n\n\n
          • Dementia<\/li>\n\n\n\n
          • Hot flashes<\/li>\n\n\n\n
          • Generalized anxiety disorder (GAD)<\/li>\n\n\n\n
          • Fibromyalgia<\/li>\n\n\n\n
          • Migraines<\/li>\n\n\n\n
          • Personality disorders<\/li>\n\n\n\n
          • Tourette syndrome<\/li>\n\n\n\n
          • Premature ejaculation<\/li>\n<\/ul>\n\n\n\n

            Zoloft Costs<\/h3>\n\n\n\n

            Brand-name Zoloft can cost between $215 and $315 for a 30-day supply. Many insurances don\u2019t cover the brand name because of these high prices. <\/p>\n\n\n\n

            Fortunately, sertraline\u2014Zoloft\u2019s generic counterpart\u2014is much more affordable and covered by Medicare and many major insurance companies. Depending on the dosage, a 30-day supply costs between $4.00 and $25.   <\/p>\n\n\n\n

            Zoloft Side Effects<\/h3>\n\n\n\n

            Each person will experience side effects differently. You should always contact your healthcare provider if any of these side effects worsen or are ongoing. <\/p>\n\n\n\n

            Common side effects of Zoloft include: <\/p>\n\n\n\n

              \n
            • Nausea or indigestion<\/li>\n\n\n\n
            • Diarrhea or loose stool<\/li>\n\n\n\n
            • Tremors or twitching<\/li>\n\n\n\n
            • Decreased appetite and weight loss<\/li>\n\n\n\n
            • Bruising and muscle aches<\/li>\n\n\n\n
            • Decreased libido\/trouble orgasming<\/li>\n\n\n\n
            • Excessive sweating<\/li>\n\n\n\n
            • Anxiety<\/li>\n<\/ul>\n\n\n\n

              Rarer but more serious side effects include: <\/p>\n\n\n\n

                \n
              • Heart arrhythmia<\/li>\n\n\n\n
              • Bleeding and liver injury<\/li>\n\n\n\n
              • Confusion and seizures<\/li>\n\n\n\n
              • Suicidal thoughts<\/li>\n\n\n\n
              • Changes in behavior<\/li>\n<\/ul>\n\n\n\n

                SSRIs may also cause serotonin syndrome, a condition caused by too much serotonin in the body. Symptoms include diarrhea, confusion, seizures, and rapid heart rate. If left untreated serotonin syndrome can have serious adverse effects.<\/p>\n\n\n\n

                Contact your health care provider immediately if you experience any severe side effects. <\/p>\n\n\n\n

                Zoloft Warnings For Use<\/h3>\n\n\n\n

                Zoloft should be taken exactly as prescribed and you should not stop taking it unless your healthcare provider has instructed you to do so in order to avoid withdrawal symptoms. If you experience depression and have sudden changes in mood or behavior or increased thoughts of suicide, contact your healthcare provider immediately. <\/p>\n\n\n\n

                Those with the following conditions or circumstances should avoid taking Zoloft: <\/p>\n\n\n\n

                  \n
                • Pregnancy or breastfeeding<\/li>\n\n\n\n
                • Liver problems<\/li>\n\n\n\n
                • Epilepsy and seizure disorders <\/li>\n\n\n\n
                • Glaucoma<\/li>\n\n\n\n
                • Bipolar disorder<\/li>\n\n\n\n
                • Thyroid disease<\/li>\n<\/ul>\n\n\n\n

                  Zoloft Drug Interactions<\/h3>\n\n\n\n

                  Zoloft interacts with 646 drugs, with 152 of those being major interactions, 488 moderate interactions, and 6 minor. Major interactions include drugs like Adderall, tramadol, and trazodone. Tell your healthcare provider about any other medications you\u2019re taking before you begin using Zoloft to avoid negative side effects.<\/p>\n\n\n\n

                  The following medications and substances may have adverse interactions with Zoloft: <\/p>\n\n\n\n

                    \n
                  • Monoamine oxidase inhibitors (MAOIs)<\/li>\n\n\n\n
                  • Blood thinners<\/li>\n\n\n\n
                  • Antipsychotic and antiseizure medications<\/li>\n\n\n\n
                  • Alcohol\u2014recreational and alcohol-based medications<\/li>\n<\/ul>\n\n\n\n

                    What Is Prozac?<\/h2>\n\n\n\n

                    Prozac is the brand name for the medication fluoxetine. It\u2019s an SSRI FDA-approved to treat depression in adults and children eight years or older. It\u2019s also approved to treat OCD in adults and children seven years or older. <\/p>\n\n\n\n

                    Both the brand name and generic formula are available via prescription. Neither form is approved for treating children under 7. It\u2019s also prescribed on and off-label to treat various conditions resulting from low serotonin.  <\/p>\n\n\n\n

                    Prozac Forms and Doses<\/h3>\n\n\n\n

                    Healthcare providers may prescribe Prozac as a capsule or liquid suspension. Each capsule contains a 20 mg dose of the medication. They\u2019re smooth, oblong pills that are half white and half green. The liquid is a mint-flavored suspension that can be measured in 10 mg doses. It\u2019s usually prescribed for children under 13 years of age. <\/p>\n\n\n\n

                    Adult patients usually take 20 mg daily, gradually increasing the amount to between 60 mg and 80 mg, depending on their condition. Children may start with 10 mg or 20 mg daily and gradually raise the dosage to 60 mg if needed.<\/p>\n\n\n\n

                    Conditions Prozac Treats<\/h3>\n\n\n\n

                    Prozac has been FDA-approved to treat the following conditions: <\/p>\n\n\n\n

                      \n
                    • Anxiety and stress<\/li>\n\n\n\n
                    • Major depression<\/li>\n\n\n\n
                    • Bulimia nervosa<\/li>\n\n\n\n
                    • Premenstrual dysphoric disorder (PMDD)<\/li>\n\n\n\n
                    • Obsessive-compulsive disorder (OCD)<\/li>\n\n\n\n
                    • Panic disorder<\/li>\n\n\n\n
                    • Postpartum depression<\/li>\n\n\n\n
                    • Schizoaffective disorder<\/li>\n<\/ul>\n\n\n\n

                      Symptoms of Anxiety Prozac Can Treat<\/h4>\n\n\n\n

                      Individuals taking Prozac for anxiety most frequently experience relief from the following symptoms: <\/p>\n\n\n\n

                        \n
                      • Fear<\/li>\n\n\n\n
                      • Chronic anxiety<\/li>\n\n\n\n
                      • Intrusive or unwanted thoughts<\/li>\n\n\n\n
                      • Frequent panic attacks<\/li>\n<\/ul>\n\n\n\n

                        Symptoms of Depression Prozac Can Treat<\/h4>\n\n\n\n

                        Those taking Prozac for depression often experience relief from the following symptoms: <\/p>\n\n\n\n

                          \n
                        • Irritable, listless, or fluctuating moods<\/li>\n\n\n\n
                        • Disturbed sleep<\/li>\n\n\n\n
                        • Irregular appetite<\/li>\n\n\n\n
                        • Low energy levels<\/li>\n\n\n\n
                        • Disinterest in daily life<\/li>\n<\/ul>\n\n\n\n

                          Off-Label Uses For Prozac<\/h4>\n\n\n\n

                          Prozac can be prescribed off-label to treat: <\/p>\n\n\n\n

                            \n
                          • Anorexia nervosa<\/li>\n\n\n\n
                          • Premature ejaculation<\/li>\n\n\n\n
                          • Various anxiety disorders<\/li>\n<\/ul>\n\n\n\n

                            Prozac Costs<\/h3>\n\n\n\n

                            Depending on the dosage, brand-name Prozac can cost between $460 and nearly $1000 for a 30-day supply. Many insurances don\u2019t cover the brand-name product because it\u2019s too expensive. <\/p>\n\n\n\n

                            However, fluoxetine\u2014Prozac\u2019s generic name\u2014is much less expensive. Medicare and many major insurance companies cover it. On average, a 30-day supply of capsules costs between $3 and $4, while the solution costs around $12. Fluoxetine tablets may cost up to $100 for those requiring a high dosage.<\/p>\n\n\n\n

                            Prozac Side Effects<\/h3>\n\n\n\n

                            Side effects look different for everyone, so it\u2019s important to monitor how you\u2019re feeling once you begin taking Prozac. <\/p>\n\n\n\n

                            Common side effects of Prozac include: <\/p>\n\n\n\n

                              \n
                            • Nausea<\/li>\n\n\n\n
                            • Diarrhea or constipation<\/li>\n\n\n\n
                            • Changes in appetite<\/li>\n\n\n\n
                            • Headache and fatigue<\/li>\n\n\n\n
                            • Increased sweating<\/li>\n\n\n\n
                            • Trouble sleeping<\/li>\n\n\n\n
                            • Impotence\/sexual dysfunction<\/li>\n<\/ul>\n\n\n\n

                              Rarer but more serious side effects include: <\/p>\n\n\n\n

                                \n
                              • Fever<\/li>\n\n\n\n
                              • High blood pressure<\/li>\n\n\n\n
                              • Rigid muscles<\/li>\n\n\n\n
                              • Seizures<\/li>\n\n\n\n
                              • Kidney or respiratory failure<\/li>\n\n\n\n
                              • Disorientation or delirium<\/li>\n<\/ul>\n\n\n\n

                                Like Zoloft, Prozac may also cause serotonin syndrome and you should contact your healthcare provider immediately if you experience symptoms like insomnia, confusion, increased heart rate, high blood pressure, dilated pupils, or muscle rigidity. <\/p>\n\n\n\n

                                Prozac Warnings For Use<\/h3>\n\n\n\n

                                Those with the following conditions should avoid taking Prozac: <\/p>\n\n\n\n

                                  \n
                                • Diabetes<\/li>\n\n\n\n
                                • Liver disease<\/li>\n\n\n\n
                                • Alcohol use disorder<\/li>\n\n\n\n
                                • History of bipolar disorder<\/li>\n\n\n\n
                                • History of suicide attempts<\/li>\n\n\n\n
                                • Low blood sodium or dehydration<\/li>\n\n\n\n
                                • Seizures<\/li>\n\n\n\n
                                • Gastrointestinal ulcers<\/li>\n\n\n\n
                                • Glaucoma<\/li>\n<\/ul>\n\n\n\n

                                  Prozac Drug Interactions<\/h3>\n\n\n\n

                                  Prozac interacts with 657 drugs, with 158 major interactions, 478 moderate interactions, and 21 minor interactions. Major interactions occur with Adderall, trazodone, and Wellbutrin XL. The following medications and substances are contraindicated for use with Prozac: <\/p>\n\n\n\n

                                    \n
                                  • Monoamine oxidase inhibitors (MAOIs)<\/li>\n\n\n\n
                                  • Nonsteroidal anti-inflammatory drugs (NSAIDs)<\/li>\n\n\n\n
                                  • Aspirin and other blood thinners<\/li>\n\n\n\n
                                  • Antihistamines<\/li>\n\n\n\n
                                  • Opioid pain relievers<\/li>\n\n\n\n
                                  • St. John\u2019s wort<\/li>\n\n\n\n
                                  • Cannabis and MDMA<\/li>\n\n\n\n
                                  • Alcohol\u2014recreational and alcohol-based medications<\/li>\n<\/ul>\n\n\n\t\t
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