{"id":18299,"date":"2024-02-15T08:08:00","date_gmt":"2024-02-15T16:08:00","guid":{"rendered":"https:\/\/cms.helloklarity.com\/?p=18299"},"modified":"2024-02-16T12:54:45","modified_gmt":"2024-02-16T20:54:45","slug":"saxenda-for-weight-loss","status":"publish","type":"post","link":"https:\/\/cms.helloklarity.com\/post\/saxenda-for-weight-loss\/","title":{"rendered":"Using Saxenda for weight loss: what to expect, dosage, and side effects"},"content":{"rendered":"\n
A medication-managed approach to weight loss<\/a> has become increasingly popular for treating obesity and overweight. Some medications previously marketed for type 2 diabetes have even been approved by the Food and Drug Administration (FDA) for weight loss. Saxenda (liraglutide) is one such medication.\u00a0<\/p>\n\n\n\n Originally marketed for type 2 diabetes under the brand name Victoza, Saxenda was FDA-approved for weight loss and weight management in 2014. In this article, we learn more about using Saxenda for weight loss, including:<\/p>\n\n\n\n Saxenda (liraglutide) is an injectable prescription medication approved for weight loss and weight management. It\u2019s made by Novo Nordisk and often prescribed as part of a medically-supervised weight loss<\/a> plan, alongside a modified diet and increased physical activity. <\/p>\n\n\n\n Saxenda is a glucagon-like peptide 1 (GLP-1) agonist medication. GLP-1 agonists work in the body by acting like the hormone GLP-1, which stimulates insulin production to lower blood sugar levels after eating. While lower blood sugar levels are helpful for controlling type 2 diabetes, it\u2019s not clear how GLP-1 agonists cause weight loss. What we do know is that GLP-1 medications appear to curb hunger, likely by delaying gastric emptying (the movement of food from the stomach into the small intestine).<\/p>\n\n\n\n Saxenda is FDA-approved for weight loss and weight management in adults and adolescents along with a reduced calorie diet and exercise who fall under the following classifications:<\/p>\n\n\n\n The retail price for a one-month supply of the maintenance dose of Saxenda is $1,430.01 according to drugs.com. <\/p>\n\n\n\n Your health insurance plan may cover a portion or all of the cost of Saxenda. Although if you don\u2019t meet the approved criteria for Saxenda use, insurance companies aren\u2019t likely to cover it. You can verify your coverage details, including any co-pays or deductibles you\u2019re required to pay, by reaching out to your insurance provider. You can also use the Novo Nordisk website to check coverage<\/a>.<\/p>\n\n\n\n Health insurance companies may require prior authorization before covering Saxenda. This process involves your provider submitting paperwork to justify the use of Saxenda. The manufacturer provides steps to expedite the process on its website. <\/p>\n\n\n\n If Saxenda isn\u2019t covered by your insurance plan, talk to your healthcare provider. They may be able to write a letter of appeal to your insurance company on your behalf. You can print a sample letter<\/a> from the Novo Nordisk website and give it to your healthcare provider to submit.<\/p>\n\n\n\n There are also a few ways to make your Saxenda prescription affordable if insurance doesn\u2019t cover it. You may be eligible for a savings card<\/a> from Novo Nordisk. Additionally, websites, like GoodRx and SingleCare Rx, can help you find the best prices at pharmacies near you.<\/p>\n\n\n\n Saxenda is a GLP-1 agonist medication that acts like GLP-1, a hormone that naturally occurs in the body. GLP-1 works for weight loss<\/a> by signaling satiety, or fullness, to the brain and slowing gut movement after eating. This effectively reduces your appetite, making you feel less hungry. <\/p>\n\n\n\n Natural GLP-1 hormone only stays in the body for a few minutes. But GLP-1 agonist medications break down more slowly which helps you feel fuller throughout the day, so you\u2019re satisfied eating less.<\/p>\n\n\n\n Saxenda is intended for long-term weight management as part of a medical weight loss program<\/a> that includes diet and exercise. You should follow up with your healthcare provider 12 weeks after starting the medication to see if Saxenda is working for you, but there\u2019s no set time limit for treatment with Saxenda. The weight loss program you develop with your provider will determine how long you take Saxenda for weight loss. <\/p>\n\n\n\n One study<\/a> showed that individuals who lose weight on Saxenda tend to gain it back after stopping treatment. <\/p>\n\n\n\n It\u2019s important to follow a weight loss program that includes diet and exercise to reduce weight gain after stopping Saxenda. Work with your healthcare provider to better understand how diet and exercise work alongside medication to help you reach your weight loss goals and maintain them. <\/p>\n\n\n\n Saxenda begins to work after your first injection, but it might be a few weeks before you start to see results on the scale. This is because a lower dosage of 0.6 milligrams is taken to start and increased weekly until you reach the full maintenance dose of 3 milligrams at 5 weeks.<\/p>\n\n\n\n In clinical trials<\/a>, patients who didn\u2019t have diabetes and took the maintenance dose of 3 milligrams of Saxenda and were advised to make lifestyle changes lost between 5% and 10% of their initial body weight after 56 weeks.<\/p>\n\n\n\n Keep in mind that metabolism varies between individuals and your weight loss journey may be just as unique as you are. Talk to your healthcare provider if you have any concerns about your progress while taking Saxenda for weight loss.<\/p>\n\n\n\n Before starting treatment with Saxenda for weight loss, there are a few things to keep in mind. <\/p>\n\n\n\n Saxenda isn\u2019t recommended for patients with a personal or family history of medullary thyroid cancer (MCT) or multiple endocrine neoplasia syndrome type 2 (MEN2). Tell your provider if you or a family member have a history of thyroid cancer or other endocrine disorders. <\/p>\n\n\n\n Additionally, Saxenda isn\u2019t recommended for individuals with certain medical conditions, including gallbladder disease, pancreatitis, and kidney disease. Talk to your provider before taking Saxenda if you have or have had any of the following conditions:<\/p>\n\n\n\n History of one or more of these conditions doesn\u2019t necessarily exclude you from using Saxenda for weight loss. Your healthcare provider will review your personal and family medical history to determine whether Saxenda is the right weight loss treatment for you.<\/p>\n\n\n\n Before starting treatment with Saxenda, be sure to tell your healthcare provider of any other medications you take. There are no known specific drug interactions with Saxenda; however, Saxenda slows gut motility and may interfere with the absorption of oral medications that need to pass through the stomach. Also, combining Saxenda with diabetes medications, such as insulin and sulfonylureas, raises the risk of hypoglycemia (low blood sugar), which can be life-threatening. <\/p>\n\n\n\n Saxenda comes in pen-form (like an EpiPen) and is taken by injection under the skin in the stomach area (abdomen), upper leg (thigh), or upper arm. Make sure you\u2019re comfortable giving yourself injections or have a reliable caregiver around to help. You need to take Saxenda every day. <\/p>\n\n\n\n Your healthcare provider will show you how to perform the injection and answer any questions you may have. If you need a refresher at home, video instructions are available on Novo Nordisk\u2019s Saxenda website. <\/p>\n\n\n\n It\u2019s possible to have side effects when taking Saxenda. Mild to moderate gastrointestinal side effects are most common with Saxenda, especially in the first 4 to 8 weeks. Sometimes they only last a few days. <\/p>\n\n\n\n If you have more serious side effects on Saxenda immediately contact your healthcare provider or call 911.<\/p>\n\n\n\n Common side effects of Saxenda include:<\/p>\n\n\n\n Most of these side effects are due to changes in food intake and slowed gut movement caused by treatment with Saxenda. These typically last a few days or weeks and resolve as your body adjusts to the medication. Talk to your healthcare provider or pharmacist if these side effects continue, worsen, or interfere with your daily life. They may make suggestions for managing the side effects or even recommend discontinuing Saxenda if the side effects outweigh the benefits.<\/p>\n\n\n\n Some things you can do on your own to reduce nausea and other gastrointestinal side effects include:<\/p>\n\n\n\n If you have an injection site reaction, try the following:<\/p>\n\n\n\n Serious side effects reported with Saxenda include, but may not be limited to:<\/p>\n\n\n\n Kidney issues on Saxenda are most commonly caused by dehydration due to vomiting or diarrhea. In some cases, kidney failure occurred in patients taking other medications that affect kidney function, such as ibuprofen, alongside Saxenda. If you\u2019re concerned, talk to your healthcare provider about your risk of developing kidney issues while on Saxenda.<\/p>\n\n\n\n Talk to your healthcare provider about your risk for thyroid cancer. They may choose not to prescribe Saxenda if you have a personal or family history of certain thyroid cancers. <\/p>\n\n\n\n Contact your healthcare provider immediately if you develop these or other serious side effects while taking Saxenda. If you can\u2019t reach your provider or feel that the situation is a medical emergency, call 911.<\/p>\n\n\n\n Saxenda doesn\u2019t work for everyone and isn\u2019t recommended for certain medical conditions. Additionally, your BMI may not meet the criteria for Saxenda use. If it\u2019s not a good match for you, your healthcare provider may suggest an alternative GLP-1 agonist medication, such as Wegovy<\/a> or Zepbound. <\/p>\n\n\n\n There are currently many types of GLP-1 drugs on the market. They\u2019re mainly FDA-approved to treat type 2 diabetes; however, three GLP-1 agonists have been approved as weight loss injections<\/a>: Saxenda, Wegovy, and Zepbound. <\/p>\n\n\n\n Wegovy (semaglutide) is another GLP-1 agonist medication. Just like Saxenda, it mimics GLP-1 in the body to cause slowed gut movement and a sustained feeling of satiety. It\u2019s manufactured by the same company and is also an injectable medication. Reported side effects are similar to Saxenda.<\/p>\n\n\n\n The main difference between Wegovy and Saxenda is that Wegovy is taken less often. While Saxenda is injected daily, Wegovy lasts longer in the body and is only injected once a week. Also, the injection pens work a little differently. The Wegovy pen is prefilled with a single dosage, while the Saxenda pen contains 5 different dose options.<\/p>\n\n\n\n You may also lose more weight with Wegovy. In clinical trials comparing Wegovy and Saxenda<\/a>, patients who took Wegovy lost roughly 16% of their initial body weight on average. Patients who took Saxenda lost an average of 6% of their initial body weight.<\/p>\n\n\n\n Some studies suggest that some people tolerate Wegovy better. The clinical trial mentioned above also compared the side effects of Wegovy and Saxenda. While the 2 medications have overlapping side effects, a larger percentage of patients discontinued Saxenda, half of which reported that they discontinued due to side effects.<\/p>\n\n\n\n Zepbound (tirzepatide) is a dual-agonist medication, meaning it works on 2 hormone pathways; in this case, GLP-1 and gastric inhibitory polypeptide (GIP). Zepbound simulates both of these hormones; it acts like GLP-1 by delaying gastric emptying and causing feelings of fullness while the GIP pathway stimulates insulin release to stabilize blood sugar after eating. Like Saxenda, Zepbound comes in an injection pen and the most common side effects are gastrointestinal.<\/p>\n\n\n\n With Zepbound, weight loss appears to be dose-dependent. So depending on your dosage, you may lose more weight with Zepbound. In clinical trials<\/a>, patients taking the lowest dose of Zepbound lost an average of 15% of their initial body weight, while patients taking the highest dose lost roughly 21% of their initial body weight on average.<\/p>\n\n\n\n Other type 2 diabetes medications, such as Ozempic, Rybelsus, and Mounjaro, can also be used off-label<\/a> for weight loss at your healthcare provider\u2019s discretion. <\/p>\n\n\n\n Xenical, a lipase-inhibiting medication that reduces the amount of fat absorbed by the body, is a pill and can also be prescribed as an alternative to Saxenda. Other non-injection prescription weight-loss options include Qsymia (phentermine-topiramate), Contrave (bupropion-naltrexone), Adipex-P (phentermine), and Plenity. There\u2019s also Alli, which is a lower-dose, over-the-counter version of orlistat (Xenical). <\/p>\n\n\n\n If you\u2019re interested in weight loss medication, talk to your healthcare provider about the best prescription weight loss pill options available to you. They can help you create a plan to reach your weight loss goals that may or may not include medication.<\/p>\n\n\n\n If you\u2019re considering Saxenda as part of your weight loss program, here are some questions to ask your healthcare provider.<\/p>\n\n\n\n Before you start treatment with Saxenda, your healthcare provider will help you come up with a long-term weight management plan. This typically includes changes to diet and an exercise routine, in addition to weight loss medication. Your provider may even recommend that you work with a dietician or nutritionist when developing your weight management plan to get the best results. <\/p>\n\n\n\n Most people follow up with their provider at 12 weeks to review their progress and renew their prescription. Your provider may ask to follow up sooner depending on your health history.<\/p>\n\n\n\n After you stop treatment with Saxenda, you may experience increased appetite because Saxenda works by limiting how hungry you feel. As your body adjusts, you may experience weight gain and indigestion. Be sure to consult your provider before you stop taking Saxenda. They can help you understand what to expect and how to manage any side effects. They may also want to wean you off gradually to help minimize the effects.<\/p>\n\n\n\n Saxenda is administered by self-injection once daily. Your healthcare provider or pharmacist can show you how to give yourself the injection. It\u2019s injected under the skin in the abdomen, thigh, or upper arm. Saxenda should never be injected into a muscle or vein.<\/p>\n\n\n\n Saxenda can be taken at any time of day, independent of meals. It\u2019s recommended that you take it at the same time every day to get the best results. Try to choose a time that is convenient for you and easy to remember. Consider setting a reminder on your phone so you don\u2019t miss a dose.<\/p>\n\n\n\n\n
What is Saxenda for weight loss?<\/h2>\n\n\n\n
Who can take Saxenda for weight loss?<\/h3>\n\n\n\n
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What does Saxenda cost and is it covered by health insurance?<\/h3>\n\n\n\n
How does Saxenda work for weight loss?<\/h2>\n\n\n\n
How long can you take Saxenda?<\/h2>\n\n\n\n
How much weight can you lose with Saxenda?<\/h3>\n\n\n\n
What to know before you start Saxenda<\/h2>\n\n\n\n
Saxenda isn\u2019t recommended for everyone<\/h3>\n\n\n\n
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Saxenda may interfere with other medications<\/h3>\n\n\n\n
Saxenda is an injectable medication<\/h3>\n\n\n\n
What are the side effects of Saxenda?<\/h2>\n\n\n\n
Common side effects of Saxenda and what to do<\/h3>\n\n\n\n
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Serious side effects of Saxenda<\/h3>\n\n\n\n
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Symptoms can include:\n\n
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<\/strong>Saxenda has an FDA black box warning for the risk of medullary thyroid cancer. In animal studies, liraglutide was reported to cause medullary thyroid cancer (MTC). It\u2019s not yet clear if there\u2019s a risk to humans. <\/li>\n<\/ul>\n\n\n\nAre there alternatives to Saxenda?<\/h2>\n\n\n\n
Wegovy as an alternative to Saxenda<\/h3>\n\n\n\n
Zepbound as an alternative to Saxenda<\/h3>\n\n\n\n
Other alternatives to Saxenda<\/h3>\n\n\n\n
What to ask your healthcare provider<\/h2>\n\n\n\n
What should I expect when starting treatment with Saxenda?<\/h3>\n\n\n\n
When should we follow up?<\/h3>\n\n\n\n
What should I expect after stopping treatment with Saxenda?<\/h3>\n\n\n\n
How do I take Saxenda?<\/h3>\n\n\n\n
How do I handle and dispose of the needles?<\/h3>\n\n\n\n