{"id":12372,"date":"2023-05-05T11:26:26","date_gmt":"2023-05-05T18:26:26","guid":{"rendered":"https:\/\/cms.helloklarity.com\/?p=12372"},"modified":"2023-12-20T11:52:07","modified_gmt":"2023-12-20T19:52:07","slug":"doxepin-vs-protriptyline","status":"publish","type":"post","link":"https:\/\/cms.helloklarity.com\/post\/doxepin-vs-protriptyline\/","title":{"rendered":"Doxepin vs. Protriptyline"},"content":{"rendered":"\n

Finding the right treatment for your depression symptoms can take time as you and your healthcare provider work to adjust your doses and navigate side effects. <\/p>\n\n\n\n

While doxepin and protriptyline are tricyclic antidepressants that may not work for everyone, they could be good alternatives for you if your current medications aren\u2019t working. In this post, we\u2019ll compare doxepin vs. protriptyline, including their side effects, warnings, and interactions so that you can have an informed discussion with your care provider. <\/p>\n\n\n\n

Discover the right medication for your depression symptoms with a trusted care provider from the comfort of your own home. Schedule an appointment<\/a>, and Klarity will connect you with a licensed medical provider within 48 hours so that you can get the care you need to find relief.<\/p>\n\n\n\n

This article discusses suicide, suicidal ideation, and self-harm. If you or someone you know is experiencing suicidal thoughts or is in crisis, contact the Suicide Prevention Lifeline immediately at 800-273-8255.<\/em><\/p>\n\n\n\n

Protriptyline and Doxepin Are the Same Class of Drugs (Tricyclics)<\/h2>\n\n\n\n

Protriptyline and doxepin are both tricyclic antidepressants prescribed to treat depression. While they belong to the same class of drugs, they have different uses, doses, and side effects.<\/p>\n\n\n\n

What are Tricyclics?<\/h3>\n\n\n\n

Tricyclic antidepressants impact the chemical messengers (neurotransmitters) in the brain and work to ease symptoms of depression. These neurotransmitters block the reabsorption of serotonin and norepinephrine, which help regulate mood. With more serotonin and norepinephrine in your system, you\u2019re more likely to experience boosts in mood and alertness.<\/p>\n\n\n\n

Protriptyline and Doxepin Are Both Used to Treat Major Depressive Disorder<\/h2>\n\n\n\n

Protriptyline and doxepin are prescribed to treat major depressive disorder, but they have a number of possible side effects. <\/p>\n\n\n\n

What Else Does Protriptyline Treat?<\/h3>\n\n\n\n

Protriptyline is FDA-approved to treat depression, but it can also be prescribed to treat other issues on an off-label basis. <\/p>\n\n\n\n

Off-Label Uses for Protriptyline<\/h4>\n\n\n\n

Off-label use means that your healthcare provider is prescribing a medication that\u2019s been approved by the FDA to treat a particular condition you do not have. For example, protriptyline is primarily FDA-approved to treat depression, but it can be prescribed off-label for anxiety, ADHD, narcolepsy, and headaches as well. <\/p>\n\n\n\n

Additionally, a medication may be used in an off-label capacity if your healthcare provider prescribes it in a different form or dose than what\u2019s been FDA-approved. So, if your medication typically comes as a capsule, but your healthcare provider deems an oral solution to be the better choice for you, that would be considered an off-label prescription. <\/p>\n\n\n\n

Ultimately, off-label use means that the medication hasn\u2019t been through the same tests as FDA-approved medications. Off-label prescriptions are not uncommon, and your healthcare provider can offer you the best guidance as to what\u2019s right for you. <\/p>\n\n\n\n

What Else Does Doxepin Treat?<\/h3>\n\n\n\n

Doxepin is FDA-approved to treat depression and anxiety, but like protriptyline, it also has off-label uses.<\/p>\n\n\n\n

Off-Label Uses for Doxepin<\/h4>\n\n\n\n

If you experience trouble sleeping, your healthcare provider may prescribe doxepin to help alleviate insomnia symptoms. This medication can make you drowsy and allow you to fall asleep more easily and stay asleep longer.<\/p>\n\n\n\n

Doses, Dosage Form, and Side Effects of Doxepin<\/h2>\n\n\n\n

Depending on the severity of your symptoms and your doctor’s recommendation, the form, and dosage you take will vary. <\/p>\n\n\n\n

Common Doxepin Doses and Forms<\/h3>\n\n\n\n

Doxepin can be taken as a liquid, tablet, or capsule. For those experiencing mild symptoms, your healthcare provider may prescribe a lower dose, like 25-50 mg, to be taken once a day. If your symptoms are more severe, the typical adult dosage is 75-150 mg daily, with a maximum dose of 300 mg.<\/p>\n\n\n\n

Once you begin taking doxepin, it may take two to three weeks for the antidepressant to take effect. If you\u2019re prescribed doxepin for anxiety, you\u2019ll likely see results soon after you begin using it. <\/p>\n\n\n\n

Common Doxepin Side Effects<\/h3>\n\n\n\n

Doxepin has several side effects, including:<\/p>\n\n\n\n

    \n
  • Dizziness<\/li>\n\n\n\n
  • Dilated pupils<\/li>\n\n\n\n
  • Mouth sores<\/li>\n\n\n\n
  • Sensitivity to sunlight on your skin<\/li>\n\n\n\n
  • Flushing<\/li>\n\n\n\n
  • Digestive problems<\/li>\n\n\n\n
  • Difficulty urinating<\/li>\n\n\n\n
  • Changes in sex drive<\/li>\n\n\n\n
  • Excessive sweating<\/li>\n\n\n\n
  • Chills<\/li>\n\n\n\n
  • Headache<\/li>\n\n\n\n
  • Hair loss<\/li>\n\n\n\n
  • Increased breast size <\/li>\n\n\n\n
  • Swollen testes <\/li>\n\n\n\n
  • Milky discharge from the nipple (in females)<\/li>\n\n\n\n
  • Nausea<\/li>\n\n\n\n
  • Vomiting<\/li>\n\n\n\n
  • Weakness<\/li>\n\n\n\n
  • Weight gain or weight loss<\/li>\n\n\n\n
  • Loss of appetite<\/li>\n\n\n\n
  • Dry mouth<\/li>\n<\/ul>\n\n\n\n

    If you have more serious side effects like increased heart rate, yellowing skin or eyes, unusual bleeding or bruising, and skin irritation or swelling, contact your healthcare provider immediately.<\/p>\n\n\n\n

    Common Doxepin Drug Interactions<\/h3>\n\n\n\n

    Doxepin has varying interactions with 20 commonly prescribed medications. Major interactions include Cymbalta, Flexeril, Lexapro, Topamax, and Zoloft. <\/p>\n\n\n\n

    Moderate interactions can occur with the following medications:<\/p>\n\n\n\n

      \n
    • Abilify<\/li>\n\n\n\n
    • Adderall<\/li>\n\n\n\n
    • Ambien<\/li>\n\n\n\n
    • Benadryl<\/li>\n\n\n\n
    • Klonopin<\/li>\n\n\n\n
    • Lamictal<\/li>\n\n\n\n
    • Lyrica<\/li>\n\n\n\n
    • Norco<\/li>\n\n\n\n
    • Seroquel<\/li>\n\n\n\n
    • Synthroid<\/li>\n\n\n\n
    • Xanax<\/li>\n\n\n\n
    • Zyrtec<\/li>\n<\/ul>\n\n\n\n

      Doxepin also interacts with 27 diseases, including cardiovascular diseases, seizure disorders, depression, and others. Talk with your care provider about your medical history before taking any new medication. <\/p>\n\n\n\n

      Taking doxepin while drinking alcohol can change or increase its effects, and you should always discuss it with your healthcare provider before mixing the two. <\/p>\n\n\n\n

      How Much Does Doxepin Cost?<\/h3>\n\n\n\n

      How much you pay for doxepin depends on your pharmacy and the dosage your healthcare provider prescribes. If you\u2019re paying cash, you can expect your prescription to cost anywhere from $17 to $292. That said, you may be able to find more affordable monthly options if you have insurance.<\/p>\n\n\n\n

      Doses, Dosage Form, and Side Effects of Protriptyline<\/h2>\n\n\n\n

      Everyone experiences protriptyline differently depending on their current symptoms and medical history. Always discuss new medications with your healthcare provider beforehand.<\/p>\n\n\n\n

      Common Protriptyline Doses and Forms<\/h3>\n\n\n\n

      Protriptyline comes in tablet form, and the adult dose typically starts between 15 to 40 mg daily. If your healthcare provider recommends a higher amount to treat your symptoms, they may increase it to a maximum of 60 mg per day. The dosage can be lower for teenagers and older adults, starting at 5 mg daily. <\/p>\n\n\n\n

      Common Side Effects of Protriptyline<\/h3>\n\n\n\n

      Like doxepin, protriptyline also has the following side effects:<\/p>\n\n\n\n

        \n
      • Changes in urination<\/li>\n\n\n\n
      • Excessive sweating<\/li>\n\n\n\n
      • Dizziness<\/li>\n\n\n\n
      • Chills<\/li>\n\n\n\n
      • Weakness<\/li>\n\n\n\n
      • Weight gain or loss<\/li>\n<\/ul>\n\n\n\n

        Beyond those side effects, you can also experience:<\/p>\n\n\n\n

          \n
        • Stomach pain<\/li>\n\n\n\n
        • Irritability<\/li>\n\n\n\n
        • Vision issues<\/li>\n\n\n\n
        • Clay-colored stool<\/li>\n\n\n\n
        • Chest pain<\/li>\n\n\n\n
        • Confusion<\/li>\n\n\n\n
        • Ringing in the ears<\/li>\n\n\n\n
        • Difficulty speaking<\/li>\n\n\n\n
        • Irregular heartbeat<\/li>\n\n\n\n
        • Fever<\/li>\n\n\n\n
        • Hallucinations<\/li>\n\n\n\n
        • Hearing issues<\/li>\n\n\n\n
        • Lower back pain<\/li>\n\n\n\n
        • Sores or ulcers in the mouth<\/li>\n\n\n\n
        • Difficulty sleeping<\/li>\n\n\n\n
        • Tics in the face, neck, and back<\/li>\n\n\n\n
        • Yellow eyes or skin<\/li>\n<\/ul>\n\n\n\n

          If you experience symptoms of overdose, like a change in consciousness, disorientation, dilated pupils, excessive drowsiness, or trouble breathing, contact emergency medical services immediately. <\/p>\n\n\n\n

          Common Protriptyline Drug Interactions<\/h3>\n\n\n\n

          Protriptyline interacts with 20 most frequently checked medications. Major interactions include Cymbalta, Trintellix, and Zoloft. <\/p>\n\n\n\n

          Protriptyline has moderate interactions with the following:<\/p>\n\n\n\n

            \n
          • Abilify<\/li>\n\n\n\n
          • Adderall<\/li>\n\n\n\n
          • Benadryl<\/li>\n\n\n\n
          • Bentyl<\/li>\n\n\n\n
          • Klonopin<\/li>\n\n\n\n
          • Lyrica<\/li>\n\n\n\n
          • Nuvigil<\/li>\n\n\n\n
          • Synthroid<\/li>\n\n\n\n
          • Zyrtec<\/li>\n<\/ul>\n\n\n\n

            Additionally, there are several diseases that interact with protriptyline, including cardiovascular diseases, depression, seizure disorders, and certain psychiatric disorders. <\/p>\n\n\n\n

            Like doxepin, drinking alcohol while taking protriptyline can alter its effects, so it\u2019s important to talk with a healthcare professional before doing so. <\/p>\n\n\n\n

            How Much Does Protriptyline Cost?<\/h3>\n\n\n\n

            Your costs will vary depending on your prescription, the pharmacy you use, and your insurance coverage plan. If you\u2019re paying cash, protriptyline can start at $55 per month for 30 tablets of 10 mg.<\/p>\n\n\n\n

            Do I Need a Prescription for Protriptyline or Doxepin?<\/h2>\n\n\n\n

            Yes, you need a prescription from a trusted medical provider for protriptyline and doxepin.<\/p>\n\n\n\n

            Other Tricyclic Side Effects<\/h2>\n\n\n\n

            Tricyclic antidepressants are not the first-line choice for treating depression, as they have many possible side effects, including serotonin syndrome, pregnancy or breastfeeding issues, risk of abnormal bleeding, and they come with a black box warning.<\/p>\n\n\n\n

            Serotonin Syndrome<\/h3>\n\n\n\n

            Serotonin syndrome can be fatal and is brought on by using medications that boost your serotonin levels, like tricyclic antidepressants. You can experience mild symptoms of serotonin syndrome, including diarrhea or nausea, to severe symptoms like high fever and seizures. You must take your tricyclic antidepressants exactly as prescribed to avoid this.  <\/p>\n\n\n\n

            Pregnancy and Breastfeeding on Tricyclics<\/h3>\n\n\n\n

            Talk with your healthcare provider before taking tricyclics while pregnant or breastfeeding. In some cases, tricyclic antidepressants can result in birth abnormalities, fetal withdrawal symptoms, and excessive drowsiness while breastfeeding. <\/p>\n\n\n\n

            Increased Bleeding Risk with Tricyclics<\/h3>\n\n\n\n

            Tricyclics impact blood levels, which can lead to an increased risk of internal bleeding. This is especially true if you\u2019re taking tricyclic antidepressants with blood thinners. <\/p>\n\n\n\n

            Black Box Warning with Antidepressants<\/h3>\n\n\n\n

            Both doxepin and protriptyline are tricyclic antidepressants that come with black box warnings. This warning, the highest warning issued by the U.S. Food and Drug Administration, indicates that antidepressants like doxepin and protriptyline have an increased risk of suicidal thoughts and behaviors. <\/p>\n\n\n\t\t

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